NSC 33994
Tocris Bioscience, part of Bio-Techne | Catalog # 4338
JAK2 inhibitor
Discontinued Product
4338 has been discontinued.
View all JAK Kinase Inhibitors products.
Product Description
NSC 33994 is a selective inhibitor of JAK2 (IC50 = 60 nM). Displays no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.Product Specifications
Molecular Weight
438.65
Formula
C28H42N2O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
E-4,4'-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]phenol
CAS Number
82058-16-0
PubChem ID
5473838
InChI Key
QFNJFVBKASKGEU-OCEACIFDSA-N
SMILES
CC/C(C2=CC=C(O)C(CN(CC)CC)=C2)=C(CC)\C1=CC(CN(CC)CC)=C(O)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 2.19 | 5 with gentle warming | |
| Ethanol | 4.39 | 10 with gentle warming |
Preparing Stock Solutions
for NSC 33994
The following data is based on the product molecular weight 438.65
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.80 mL | 113.99 mL | 227.97 mL |
| 0.5 mM | 4.56 mL | 22.80 mL | 45.59 mL |
| 1 mM | 2.28 mL | 11.40 mL | 22.80 mL |
| 5 mM | 0.46 mL | 2.28 mL | 4.56 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Kiss Identification of a novel inhibitor of JAK2 tyrosine kinase by structure-based virtual screening. Bioorg.Med.Chem.Lett. 2009 PMID: 19447617
Product Specific Notices for NSC 33994
For research use only
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