NS 9283

Tocris Bioscience, part of Bio-Techne | Catalog # 5112

Positive allosteric modulator of α4β2 nAChRs
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Key Product Details

Description

Positive allosteric modulator of α4β2 nAChRs

View all Nicotinic (a4b2) Receptor Modulators »

Product Description

NS 9283 is a positive allosteric modulator of α4β2 receptor; increases the potency of Ach-evoked currents ~60 fold without affecting the maximum efficacy (HEK293-hα4β2 cells). Reduces the rate of recovery from desensitization and slows the rate of deactivation. Displays a synergistic effect on the Emax when given with NS206 at 3α:2β receptors.

Product Specifications

Molecular Weight

248.24

Formula

C14H8N4O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

3-[3-(3-Pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile

CAS Number

913830-15-6

PubChem ID

11998180

InChI Key

HGFXDSQLRSWUBO-UHFFFAOYSA-N

SMILES

N#CC1=CC(C2=NC(C3=CN=CC=C3)=NO2)=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1eq. HCl 4.96 20
DMSO 12.41 50

Preparing Stock Solutions for NS 9283

The following data is based on the product molecular weight 248.24

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 8.06 mL 40.28 mL 80.57 mL
2.5 mM 1.61 mL 8.06 mL 16.11 mL
5 mM 0.81 mL 4.03 mL 8.06 mL
25 mM 0.16 mL 0.81 mL 1.61 mL

Calculators

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Product Documents for NS 9283

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NS 9283

For research use only

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