NS 1738

Name: NS 1738
Brand: Tocris Bioscience
SKU: 2995
Price: 194 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 2995

Citations (3)

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Key Product Details

Description:	Positive allosteric modulator of α7 nAChRs; active in vivo
Chemical Name:	N-(5-Chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]urea
Purity:	≥98% (HPLC)
Molecular Weight:	365.13

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Biological Activity for NS 1738

NS 1738 is a selective positive allosteric modulator of α7 nicotinic acetylcholine receptors. Exhibits no substantial activity for α4β2, α3β3 and α1-containing receptors. Displays cognitive-enhancing properties in vivo.

Compound Libraries for NS 1738

NS 1738 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NS 1738

M. Wt	365.13
Formula	C₁₄H₉Cl₂F₃N₂O₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	501684-93-1
PubChem ID	310378
InChi Key	OUDXRNQPVSMGDW-UHFFFAOYSA-N
Smiles	O=C(NC2=CC(C(F)(F)F)=CC=C2Cl)NC1=C(O)C=CC(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NS 1738

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	36.51	100
	ethanol	36.51	100

Preparing Stock Solutions for NS 1738

The following data is based on the product molecular weight 365.13.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.74 mL	13.69 mL	27.39 mL
5 mM	0.55 mL	2.74 mL	5.48 mL
10 mM	0.27 mL	1.37 mL	2.74 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

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References for NS 1738

References are publications that support the biological activity of the product.

Freitas The antinociceptive effects of nicotinic receptors α7-positive allosteric modulators in murine acute and tonic pain models. J.Pharmacol.Exp.Ther. 2013 PMID: 23115222
Timmermann An allosteric modulator of the α7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo. J.Pharmacol.Exp.Ther. 2007 PMID: 17625074

Citations for NS 1738 (3)

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Citations are publications that use Bio-Techne products. Selected citations for NS 1738 include:

Bali et al. (2019) Facilitation and inhibition of firing activity and N-methyl-D-aspartate-evoked responses of CA1 hippocampal pyramidal cells by alpha7 nicotinic acetylcholine receptor selective compounds in vivo. Sci Rep. 9:9324
PMID: 31249369
Chatzidaki et al. (2015) Pharmacological Characterisation of Nicotinic Acetylcholine Receptors Expressed in Human iPSC-Derived Neurons. Neuropharmacology. 10:e0125116
PMID: 25906356
Chatzidaki et al. (2015) The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptors. Int J Oncol. 97:75
PMID: 25998276

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Product Documents for NS 1738

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.