NS 1738

Tocris Bioscience, part of Bio-Techne | Catalog # 2995

Positive allosteric modulator of α7 nAChRs; active in vivo
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Key Product Details

Description

Positive allosteric modulator of α7 nAChRs; active in vivo

View all Nicotinic (a7) Receptor Modulators »

Product Description

NS 1738 is a selective positive allosteric modulator of α7 nicotinic acetylcholine receptors. Exhibits no substantial activity for α4β2, α3β3 and α1-containing receptors. Displays cognitive-enhancing properties in vivo.

Product Specifications

Molecular Weight

365.13

Formula

C14H9Cl2F3N2O2

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

N-(5-Chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]urea

CAS Number

501684-93-1

PubChem ID

310378

InChI Key

OUDXRNQPVSMGDW-UHFFFAOYSA-N

SMILES

O=C(NC2=CC(C(F)(F)F)=CC=C2Cl)NC1=C(O)C=CC(Cl)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.51 100
Ethanol 36.51 100

Preparing Stock Solutions for NS 1738

The following data is based on the product molecular weight 365.13

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.69 mL 27.39 mL
5 mM 0.55 mL 2.74 mL 5.48 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for NS 1738

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NS 1738

For research use only

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