NS 1619

Tocris Bioscience, part of Bio-Techne | Catalog # 3804

KCa1.1 (BK) channel activator
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Key Product Details

Description

KCa1.1 (BK) channel activator

View all Ca2+-Activated Potassium Channel Activators »

Product Description

NS 1619 is a large-conductance Ca2+-activated potassium (BKCa, KCa1.1) channel activator. Induces a concentration-dependent decrease in mitochondrial membrane potential (EC50 = 3.6 μM).

Product Specifications

Molecular Weight

362.23

Formula

C15H8F6N2O2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1,3-Dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-2H-benzimidazol-2-one

CAS Number

153587-01-0

PubChem ID

4552

InChI Key

YLFMCMWKHSDUCT-UHFFFAOYSA-N

SMILES

O=C2NC1=CC(C(F)(F)F)=CC=C1N2C3=CC(C(F)(F)F)=CC=C3O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.22 100
Ethanol 36.22 100

Preparing Stock Solutions for NS 1619

The following data is based on the product molecular weight 362.23

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.76 mL 13.80 mL 27.61 mL
5 mM 0.55 mL 2.76 mL 5.52 mL
10 mM 0.28 mL 1.38 mL 2.76 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

Calculators

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Reconstitution Calculator

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Background References

References are publications that support the biological activity of the product.

Product Documents for NS 1619

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NS 1619

For research use only

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