NNC 0640
Tocris Bioscience, part of Bio-Techne | Catalog # 6807
Negative allosteric modulator of glucagon and GLP-1 receptors
Key Product Details
Description
Negative allosteric modulator of glucagon and GLP-1 receptors
Product Description
NNC 0640 is a negative allosteric modulator of glucagon receptors (pKi = 7.4). Binds to external surface of the transmembrane domain. Also negative allosteric modulator of glucagon-like peptide 1 (GLP-1) receptor. Inhibits GLP-1-mediated cAMP accumulation in vitro.Product Specifications
Molecular Weight
573.67
Formula
C29H31N7O4S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[[(4-Cyclohexylphenyl)[[[3-(methylsulfonyl)phenyl]amino]carbonyl]amino]methyl]-N-2H-tetrazol-5-ylbenzamide
CAS Number
307986-98-7
PubChem ID
23549991
InChI Key
PPTKULJUDJWTSA-UHFFFAOYSA-N
SMILES
CS(=O)(C1=CC=CC(NC(N(C2=CC=C(C3CCCCC3)C=C2)CC4=CC=C(C(NC5=NN=NN5)=O)C=C4)=O)=C1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 57.37 | 100 |
Preparing Stock Solutions
for NNC 0640
The following data is based on the product molecular weight 573.67
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.74 mL | 8.72 mL | 17.43 mL |
| 5 mM | 0.35 mL | 1.74 mL | 3.49 mL |
| 10 mM | 0.17 mL | 0.87 mL | 1.74 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.35 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Jazayeri Extra-helical binding site of a glucagon receptor antagonist. Nature. 2016 PMID: 27111510
- Song Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators. Nature. 2017 PMID: 28514449
- Zhang Structure of the full-length glucagon class B g-protein-coupled receptor. Nature. 2017 PMID: 28514451
Product Specific Notices for NNC 0640
For research use only
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