NLS-StAx-h

Name: NLS-StAx-h
Brand: Tocris Bioscience
SKU: 6531

Tocris Bioscience, part of Bio-Techne | Catalog # 6531

Citations (1)

COA / SDS

Wnt signaling inhibitor; inhibits β-catenin-transcription factor interactions

Key Product Details

Description:	Wnt signaling inhibitor; inhibits β-catenin-transcription factor interactions
Purity:	≥95% (HPLC)
Molecular Weight:	3445.26

View Full Technical Details for NLS-StAx-h

Technical Data
Citations

Biological Activity for NLS-StAx-h

NLS-StAx-h is a Wnt inhibitor (IC₅₀ = 1.4 μM). Stapled peptide inhibitor of oncogenic Wnt signaling. Inhibits β-catenin-transcription factor interactions. Inhibits proliferation and migration of colorectal cancer cells. Cell permeable.

Technical Data for NLS-StAx-h

M. Wt	3445.26
Formula	C₁₆₁H₂₇₅N₅₅O₂₉
Single Letter Sequence	PKKKRKVRRWPRXILDXHVRRVWR (Modifications: Val-7 = Val-PEG2, Arg-8 = Arg-9 = Arg-12 = Arg-20 = Arg-21 = homo-Arg, X = (S)-2-(4-pentenyl)alanine, X-13 and X-17 stapled together with a double bond, Arg-24 = homo-Arg & C-terminal amide)
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	2872559-21-0
InChi Key	NQDXIROEXUQMGO-YCYPXFDESA-N
Smiles	O=C([C@H]1NCCC1)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCCOCCOCC(N[C@H](C(N[C@H](C(N[C@H](C(N2[C@H](C(N[C@H](C(N[C@@](CCC/C=C\CCC[C@](C)(NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CCCCNC(N)=N)=O)CC4=CNC5=CC=CC=C45)=O)C(C)C)=O)CCCCNC(N)=N)=O)CCCCNC(N)=N)=O)C(C)C)=O)CC6=CNC=N6)=O)(C(N[C@H](C(N[C@H](C(N[C@H]3CC(O)=O)=O)CC(C)C)=O)[C@H](CC)C)=O)C)=O)CCCCNC(N)=N)=O)CCC2)=O)CC7=CNC8=CC=CC=C78)=O)CCCCNC(N)=N)=O)CCCCNC(N)=N)=O)=O)C(C)C)=O)CCCCN)=O)CCCNC(N)=N)=O)CCCCN)=O)CCCCN)=O)CCCCN

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NLS-StAx-h

Solubility

Soluble to 1mg/ml in water

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References for NLS-StAx-h

References are publications that support the biological activity of the product.

Dietrich Cell permeable stapled peptide inhibitor of Wnt signaling that targets β-catenin protein-protein Interactions. Cell Chem.Biol. 2017 PMID: 28757184