NKY 80
Tocris Bioscience, part of Bio-Techne | Catalog # 5071
Adenylyl cyclase inhibitor
Product Description
NKY 80 is an inhibitor of adenylyl cyclase (AC). Exhibits greater affinity for AC5 over AC3 and AC2 (IC50 values are 8.3 μM, 132 μM and 1.7 mM respectively).Product Specifications
Molecular Weight
229.23
Formula
C12H11N3O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
2-Amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone
CAS Number
299442-43-6
PubChem ID
2772368
InChI Key
SOJUSNIBPPMLCC-UHFFFAOYSA-N
SMILES
NC(N=C2)=NC1=C2C(CC(C3=CC=CO3)C1)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.92 | 100 | |
| Ethanol | 2.29 | 10 with gentle warming |
Preparing Stock Solutions
for NKY 80
The following data is based on the product molecular weight 229.23
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.36 mL | 21.81 mL | 43.62 mL |
| 5 mM | 0.87 mL | 4.36 mL | 8.72 mL |
| 10 mM | 0.44 mL | 2.18 mL | 4.36 mL |
| 50 mM | 0.09 mL | 0.44 mL | 0.87 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Pierre Capturing adenylyl cyclases as potential drug targets. Nat.Rev.Drug Discov. 2009 PMID: 19337273
- Onda Type-specific regulation regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms. J.Biol.Chem. 2001 PMID: 11602596
Product Specific Notices for NKY 80
For research use only
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