NKY 80

Name: NKY 80
Brand: Tocris Bioscience
SKU: 5071

Tocris Bioscience a Bio-Techne Brand

Catalog # 5071

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Key Product Details

Description:	Adenylyl cyclase inhibitor
Chemical Name:	2-Amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone
Purity:	≥98% (HPLC)
Molecular Weight:	229.23

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Biological Activity for NKY 80

NKY 80 is an inhibitor of adenylyl cyclase (AC). Exhibits greater affinity for AC5 over AC3 and AC2 (IC₅₀ values are 8.3 μM, 132 μM and 1.7 mM respectively).

Compound Libraries for NKY 80

NKY 80 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for NKY 80

M. Wt	229.23
Formula	C₁₂H₁₁N₃O₂
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	299442-43-6
PubChem ID	2772368
InChi Key	SOJUSNIBPPMLCC-UHFFFAOYSA-N
Smiles	NC(N=C2)=NC1=C2C(CC(C3=CC=CO3)C1)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NKY 80

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	22.92	100
	ethanol	2.29	10 with gentle warming

Preparing Stock Solutions for NKY 80

The following data is based on the product molecular weight 229.23.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.36 mL	21.81 mL	43.62 mL
5 mM	0.87 mL	4.36 mL	8.72 mL
10 mM	0.44 mL	2.18 mL	4.36 mL
50 mM	0.09 mL	0.44 mL	0.87 mL

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Reconstitution Calculator

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References for NKY 80

References are publications that support the biological activity of the product.

Pierre Capturing adenylyl cyclases as potential drug targets. Nat.Rev.Drug Discov. 2009 PMID: 19337273
Onda Type-specific regulation regulation of adenylyl cyclase. Selective pharmacological stimulation and inhibition of adenylyl cyclase isoforms. J.Biol.Chem. 2001 PMID: 11602596

Citations for NKY 80

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NKY 80

Tocris Bioscience a Bio-Techne Brand

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