Nisoxetine hydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1025
Noradrenalin re-uptake inhibitor
Key Product Details
Description
Noradrenalin re-uptake inhibitor
Product Description
Nisoxetine hydrochloride is a potent and selective inhibitor of noradrenalin uptake with little or no affinity for a range of other neurotransmitter receptors.Product Specifications
Molecular Weight
307.82
Formula
C17H21NO2.HCl
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
(±)-γ-(2-Methoxyphenoxy)-N-methylbenzenepropanamine hydrochloride
CAS Number
57754-86-6
PubChem ID
134453
InChI Key
LCEURBZEQJZUPV-UHFFFAOYSA-N
SMILES
Cl.CNCCC(OC1=CC=CC=C1OC)C1=CC=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 30.78 | 100 |
Preparing Stock Solutions
for Nisoxetine hydrochloride
The following data is based on the product molecular weight 307.82
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.25 mL | 16.24 mL | 32.49 mL |
| 5 mM | 0.65 mL | 3.25 mL | 6.50 mL |
| 10 mM | 0.32 mL | 1.62 mL | 3.25 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.65 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zhu Down-regulation of NE transporters on PC12 cells by transporter inhibitors. J.Neurochem. 1997 PMID: 8978719
- Shearman and Meyer NE transporters in rat placenta labeled with [3H]nisoxetine. J.Pharmacol.Exp.Ther. 1998 PMID: 9454822
- Wong dl-N-Methyl-3-(o-methoxyphenoxy)-3-phenylpropylamine hydrochloride, Lilly 94939, a potent inhibitor for uptake of NE into rat brain synaptosomes and heart. Life Sci. 1975 PMID: 1207394
- Cheetham [3H]Nisoxetine - a radioligand for noradrenaline reuptake sites: correlation with inhibition of [3H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments. Neuropharmacology 1996 PMID: 8684598
Product Specific Notices for Nisoxetine hydrochloride
For research use only
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