Nisoxetine hydrochloride

Name: Nisoxetine hydrochloride
Brand: Tocris Bioscience
SKU: 1025

Catalog # 1025

Citations (5)

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Key Product Details

Description:	Noradrenalin re-uptake inhibitor
Chemical Name:	(±)-γ-(2-Methoxyphenoxy)-N-methylbenzenepropanamine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	307.82

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Biological Activity

Nisoxetine hydrochloride is a potent and selective inhibitor of noradrenalin uptake with little or no affinity for a range of other neurotransmitter receptors.

Technical Data

M. Wt	307.82
Formula	C₁₇H₂₁NO₂.HCl
Storage	Store at RT
Purity	≥99% (HPLC)
CAS Number	57754-86-6
PubChem ID	134453
InChi Key	LCEURBZEQJZUPV-UHFFFAOYSA-N
Smiles	Cl.CNCCC(OC1=CC=CC=C1OC)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	30.78	100

Preparing Stock Solutions

The following data is based on the product molecular weight 307.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.25 mL	16.24 mL	32.49 mL
5 mM	0.65 mL	3.25 mL	6.50 mL
10 mM	0.32 mL	1.62 mL	3.25 mL
50 mM	0.06 mL	0.32 mL	0.65 mL

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References

References are publications that support the biological activity of the product.

Shearman and Meyer NE transporters in rat placenta labeled with [³H]nisoxetine. J.Pharmacol.Exp.Ther. 1998 PMID: 9454822
Zhu Down-regulation of NE transporters on PC12 cells by transporter inhibitors. J.Neurochem. 1997 PMID: 8978719
Cheetham [³H]Nisoxetine - a radioligand for noradrenaline reuptake sites: correlation with inhibition of [³H]noradrenaline uptake and effect of DSP-4 lesioning and antidepressant treatments. Neuropharmacology 1996 PMID: 8684598
Wong dl-N-Methyl-3-(o-methoxyphenoxy)-3-phenylpropylamine hydrochloride, Lilly 94939, a potent inhibitor for uptake of NE into rat brain synaptosomes and heart. Life Sci. 1975 PMID: 1207394

Citations for Nisoxetine hydrochloride (5)

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Citations are publications that use Bio-Techne products. Selected citations for Nisoxetine hydrochloride include:

Bassi et al. (2019) Transient Receptor Potential Vanilloid 1 Modulates Central Inflammation in Multiple Sclerosis. Front Neurol. 10:30
PMID: 30761069
Poulin et al. (2014) Fluoxetine blocks Nav1.5 channels via a mechanism similar to that of class 1 antiarrhythmics. Mol Pharmacol. 86:378
PMID: 25028482
Nolan et al. (2014) Discovery of novel-scaffold monoamine transporter ligands via in silico screening with the S1 pocket of the serotonin transporter. ACS Chem Neurosci. 5:784
PMID: 25003748
Xu et al. (2010) Amphetamine modulation of long-term potentiation in the prefrontal cortex: dose dependency, monoaminergic contributions, and paradoxical rescue in hyperDArgic mutant. J Neurosci. 115:1643
PMID: 20969573
Li et al. (2009) Activation of glycogen synthase kinase-3 β is required for hyperDA and D2 receptor-mediated inhibition of synaptic NMDA receptor function in the rat prefrontal cortex. Front Cell Neurosci. 29:15551
PMID: 20007479

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