Nimodipine
Tocris Bioscience, part of Bio-Techne | Catalog # 0600
CaV1.x blocker
Product Description
Nimodipine is a L-type Ca2+ channel blocker. Induces autophagy. Nimodipine is modulating pericytes and other inflammation signals like Hypoxia and leukocyte stalling to improve cognitive function in Alzheimer’s disease. Nimodipine reduces pericytes and other inflammation signals like hypoxia and leukocyte stalling and improves cognitive function in Alzheimer's disease model mice.Product Specifications
Molecular Weight
418.45
Formula
C21H26N2O7
Storage
Store at RT
Purity
≥98% (HPLC)
Chemical Name
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methyloxyethyl 1-methylethyl ester
CAS Number
66085-59-4
PubChem ID
4497
InChI Key
UIAGMCDKSXEBJQ-UHFFFAOYSA-N
SMILES
COCCOC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC(=C1)[N+]([O-])=O)C(=O)OC(C)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.84 | 100 |
Preparing Stock Solutions
for Nimodipine
The following data is based on the product molecular weight 418.45
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.39 mL | 11.95 mL | 23.90 mL |
| 5 mM | 0.48 mL | 2.39 mL | 4.78 mL |
| 10 mM | 0.24 mL | 1.19 mL | 2.39 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Korte Inhibiting Ca2+ channels in Alzheimer's disease model mice relaxes pericytes, improves cerebral blood flow and reduces immune cell stalling and hypoxia. Nat. Neurosci. 2024 PMID: 39294491
- Fleming Chemical modulators of autophagy as biological probes and potential therapeutics. Nat.Chem.Biol. 2011 PMID: 21164513
- Izquierdo Nimodipine and the recovery of memory. TiPS 1990 PMID: 2203191
- Kappelle Beneficial effect of the Ca2+ antagonist, nimodipine, on existing diabetic neuropathy in the BB/Wor rat. Br.J.Pharmacol. 1994 PMID: 8019766
- Batuecas Effects of chronic nimod. on working memory of old rats in relation to defects in synaptosomal calcium homeostasis. Eur.J.Pharmacol. 1998 PMID: 9696401
Product Specific Notices for Nimodipine
For research use only
⚠ WARNING: This product can expose you to chemicals including Nimodipine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
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