Key Product Details
Description: | CaV1.x blocker |
Chemical Name: | 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 346.34 |
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Citations for Nifedipine (37)
Citations are publications that use Bio-Techne products. Selected citations for Nifedipine include:
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Lopez et al.
(2022)
Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2.
Neuron.
110:2283
PMID: 35649415 -
Phelps et al.
(2022)
The Dependence of Urinary Bladder Responses on Extracellular Calcium Varies Between Muscarinic, Histamine, 5-HT (Serotonin), Neurokinin, Prostaglandin, and Angiotensin Receptor Activation
Front Physiol.
13:841181
PMID: 35431993 -
Ciappelloni et al.
(2019)
Aquaporin-4 Surface Trafficking Regulates Astrocytic Process Motility and Synaptic Activity in Health and Autoimmune Disease.
Cell Rep.
27:3860
PMID: 31242419 -
Bellono
(2017)
Molecular basis of ancestral vertebrate electroreception.
Nature.
543:391
PMID: 28264196 -
Florea et al.
(2017)
Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma.
Oncotarget.
8:22876
PMID: 28206967 -
Kraidith et al.
(2016)
Hepcidin and 1,25(OH)2D3 effectively restore Ca2+ transport in β-thalassemic mice: reciprocal phenomenon of Fe2+ and Ca2+ absorption.
Am J Physiol Endocrinol Metab.
311:E214
PMID: 27245334 -
Mauger et al.
(2016)
Targeted Intron Retention and Excision for Rapid Gene Regulation in Response to Neuronal Activity.
Neuron.
92:1266
PMID: 28009274 -
Pigott and Garthwaite
(2016)
Nitric Oxide Is Required for L-Type Ca(2+) Channel-Dependent Long-Term Potentiation in the Hippocampus.
Front Synaptic Neurosci.
8:17
PMID: 27445786 -
Hanlon et al.
(2016)
Modulation of breast cancer cell viability by a cannabinoid receptor 2 agonist, JWH-015, is calcium dependent.
Breast Cancer (Dove Med Press).
8:59
PMID: 27186076 -
Lee et al.
(2015)
N-MthD.-aspartate receptors mediate activity-dependent down-regulation of potassium channel genes during the expression of homeostatic intrinsic plasticity.
J Neurosci.
8:4
PMID: 25599691 -
Wang and Mattson
(2014)
L-type Ca2+ currents at CA1 synapses, but not CA3 or dentate granule neuron synapses, are increased in 3xTgAD mice in an age-dependent manner.
Neurobiol Aging.
35:88
PMID: 23932880 -
Armstrong and Drapeau
(2013)
Calcium channel agonists protect against neuromuscular dysfunction in a genetic model of TDP-43 mutation in ALS.
Circ Heart Fail.
33:1741
PMID: 23345247 -
Ring et al.
(2012)
GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium.
PLoS One.
7:e36874
PMID: 22590629 -
Caiati et al.
(2012)
Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses.
Sci Rep.
2:285
PMID: 22368777 -
Kaufman et al.
(2012)
Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons.
Mol Brain.
32:3992
PMID: 22442066 -
Kim et al.
(2012)
Decreased afferent excitability contributes to synaptic depression during high-frequency stimulation in hippocampal area CA1.
J Neurophysiol.
108:1965
PMID: 22773781 -
Yang et al.
(2012)
A critical role for protein tyrosine phosphatase nonreceptor type 5 in determining individual susceptibility to develop stress-related cognitive and morphological changes.
J Neurosci.
32:7550
PMID: 22649233 -
Luoma et al.
(2011)
Progesterone inhibition of voltage-gated calcium channels is a potential neuroprotective mechanism against excitotoxicity.
Steroids.
76:845
PMID: 21371490 -
Zemkova et al.
(2011)
NE causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+.
Endocrinology.
152:3842
PMID: 21828176 -
Landstrom et al.
(2011)
Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.
FEMS Immunol Med Microbiol.
4:214
PMID: 21216834 -
Xu et al.
(2011)
Mechanistic distinction between activation and inhibition of (Na(+)+K(+))-ATPase-mediated Ca2+ influx in cardiomyocytes.
Mol Cells.
406:200
PMID: 21303662 -
Abe et al.
(2011)
The Etv1/Er81 transcription factor orchestrates activity-dependent gene regulation in the terminal maturation program of cerebellar granule cells.
Mol Brain.
108:12497
PMID: 21746923 -
Kim and Rhim
(2011)
Effects of amyloid-β peptides on voltage-gated L-type Ca(V)1.2 and Ca(V)1.3 Ca(2+) channels.
Proc Natl Acad Sci U S A.
32:289
PMID: 21822937 -
Maier et al.
(2010)
Sustained glutamate receptor activation down-regulates GABAB receptors by shifting the balance from recycling to lysosomal degradation.
J Biol Chem.
285:35606
PMID: 20826795 -
Large et al.
(2010)
Ionic currents in intimal cultured synoviocytes from the rabbit.
Am J Physiol Cell Physiol.
299:C1180
PMID: 20720182 -
Kyriazis et al.
(2010)
Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel.
J Biol Chem.
285:6811
PMID: 20038578 -
Potier et al.
(2010)
Contribution of the d-Serine-Dependent Pathway to the Cellular Mechanisms Underlying Cognitive Aging.
Front Aging Neurosci.
2:1
PMID: 20552041 -
Ludwar et al.
(2009)
Two distinct mechanisms mediate potentiating effects of depolarization on synaptic transmission.
J Neurophysiol.
102:1976
PMID: 19605611 -
Kato et al.
(2009)
Non-Hebbian synaptic plasticity induced by repetitive postsynaptic action potentials.
J Neurosci.
29:11153
PMID: 19741122 -
Soriano et al.
(2008)
Specific targeting of pro-death NMDA receptor signals with differing reliance on the NR2B PDZ ligand.
Biochem Biophys Res Commun.
28:10696
PMID: 18923045 -
Shin et al.
(2008)
Dendritic glutamate release produces autocrine activation of mGluR1 in cerebellar Purkinje cells.
Proc Natl Acad Sci U S A.
105:746
PMID: 18174329 -
Villalba et al.
(2007)
Contribution of both Ca2+ entry and Ca2+ sensitization to the alpha1-adrenergic vasoconstriction of rat penile small arteries.
Am J Physiol Heart Circ Physiol.
292:H1157
PMID: 17085536 -
Ris and Godaux
(2007)
Synapse specificity of long-term potentiation breaks down with aging.
Learn Mem.
14:185
PMID: 17351142 -
Wieland et al.
(2006)
Efficient intracellular multiplication of Legionella pneumophila in human monocytes requires functional host cell L-type calcium channels.
J Neurosci.
47:296
PMID: 16831218 -
Thiagarajan et al.
(2005)
Adaptation to synaptic inactivity in hippocampal neurons.
Neuron.
47:725
PMID: 16129401 -
Fujino et al.
(2003)
Regulation of cpg15 by signaling pathways that mediate synaptic plasticity.
Mol Cell Neurosci.
24:538
PMID: 14664806 -
Hirasawa
(2003)
Nifedipine facilitates neurotransmitter release independently of calcium channels.
Proc Natl Acad Sci U S A.
100:6139
PMID: 12714685
There are no citations that match your criteria.
Customer Reviews for Nifedipine (5)
Customer Images
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Species: HumanAssay Type: In VitroCell Line/Tissue: MCF-7We used all these compounds which were dissolved in DMSO and added to fresh culture media. Concentration reference paper PMID: 27186076
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Species: OtherAssay Type: In VitroThe following concentrations we were used:1 μM Bay K, 10 μM nifedipine, 10 μM nimodipine, 300 nM omega -agatoxin, 1 μM omega -conotoxin, 5 μM mibefradil, 1 μM tetrodotoxin, 1 μM charybdotoxin, 100 nM iberiotoxin, 10 μM NS11021.
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Species: RatAssay Type: In VitroCell Line/Tissue: spinal cord neuronsEffectively blocks KCL mediated L type calcium entry in neurons. Tested in spinal cord neuron cultures at a concentration of 10 micromolar.
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Species: OtherAssay Type: In VitroCell Line/Tissue: Primary ventricular cardiomyocytesL-type Ca2+ current of guinea pig cardiomyocytes before and after nifedipine (1 µM) superfusion for 5 min. Compared to time-matched rundown, nifedipine significantly blocked L-type Ca2+ current in cardiomyocytes
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Species: HumanAssay Type: In VitroApplied to human GI smooth muscleEffective calcium channel blocker
There are no reviews that match your criteria.
⚠ WARNING: This product can expose you to chemicals including Nifedipine, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov