NIBR LTSi

Tocris Bioscience, part of Bio-Techne | Catalog # 8175

Potent and selective LATS inhibitor; activates YAP signaling
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Key Product Details

Description

Potent and selective LATS inhibitor; activates YAP signaling

View all Other Kinase Inhibitors »

Product Description

NIBR-LTSi is a potent and selective large tumor suppressor kinase (LATS) inhibitor (IC50 = 1.4 nM). Also activates YAP signaling (EC50 = 1.0 - 2.7 μM). Promotes liver organoid formation (EC50 = 0.35 μM), hepatocyte proliferation, ISC expansion, and blocks differentiation. NIBR-LTSi is orally bioavailable and suitable for use in vivo and in vitro.

Product Specifications

Molecular Weight

308.39

Formula

C18H20N4O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-[4-[(3R)-Piperidin-3-yl]oxyphenyl]-1H-pyrrolo[2,3-b]pyridin-4-amine

PubChem ID

171115368

InChI Key

IYFCFYWXRIVCTH-OAHLLOKOSA-N

SMILES

C1(NC2=CC=C(O[C@H]3CNCCC3)C=C2)=CC=NC4=C1C=CN4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 30.84 100

Preparing Stock Solutions for NIBR LTSi

The following data is based on the product molecular weight 308.39

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.24 mL 16.21 mL 32.43 mL
5 mM 0.65 mL 3.24 mL 6.49 mL
10 mM 0.32 mL 1.62 mL 3.24 mL
50 mM 0.06 mL 0.32 mL 0.65 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for NIBR LTSi

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NIBR LTSi

For research use only

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