NGI 1

Tocris Bioscience, part of Bio-Techne | Catalog # 6652

Oligosaccharyltransferase (OST) inhibitor; anti-flaviviral
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Key Product Details

Description

Oligosaccharyltransferase (OST) inhibitor; anti-flaviviral

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Product Description

NGI 1 is an oligosaccharyltransferase (OST) inhibitor; anti-flaviviral. Inhibits dengue, Zika, West Nile, and yellow fever viruses by blocking viral RNA replication (EC50 values are 0.85 and 2.2 μM for DENV and ZIKV inhibition, respectively). Selectively arrests proliferation of non-small-cell lung cancer cells that are dependent on EGFR or FGFR for survival.

Product Specifications

Molecular Weight

394.51

Formula

C17H22N4O3S2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

5-[(Dimethylamino)sulfonyl]-N-(5-methyl-2-thiazolyl)-2-(1-pyrrolidinyl)benzamide

CAS Number

790702-57-7

PubChem ID

2519269

InChI Key

QPKGRLIYJGBKJL-UHFFFAOYSA-N

SMILES

CN(S(=O)(C1=CC(C(NC2=NC=C(S2)C)=O)=C(N3CCCC3)C=C1)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.45 100

Preparing Stock Solutions for NGI 1

The following data is based on the product molecular weight 394.51

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.67 mL 25.35 mL
5 mM 0.51 mL 2.53 mL 5.07 mL
10 mM 0.25 mL 1.27 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for NGI 1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for NGI 1

For research use only

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