NFAT inhibitor, Cell Permeable

Name: NFAT inhibitor, Cell Permeable
Brand: Tocris Bioscience
SKU: 5710
Rating: 5 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 5710

(1)

Citations (3)

COA / SDS

Cell permeable NFAT inhibitor

Key Product Details

Description:	Cell permeable NFAT inhibitor
Alternative Names:	11R-VIVIT
Purity:	≥95% (HPLC)
Molecular Weight:	3573.15

View Full Technical Details for NFAT inhibitor, Cell Permeable

Technical Data
Citations / Reviews (1)

Biological Activity for NFAT inhibitor, Cell Permeable

NFAT inhibitor, Cell Permeable is an NFAT inhibitor. Inhibits LPS or LPS plus IFN-γ-induced IL-12 p40, IL-12 p70, IL-23 and TNF secretion from bone marrow-derived macrophages (BMDMs). Also attenuates NO production and Nos2 mRNA expression in LPS-stimulated BMDMs. Reduces inflammation and epithelial damage in a mouse model of colitis. In an animal model of Alzheimer's disease NFAT inhibitor improves cognitive and synaptic function, reduces glial activation and lowers amyloid levels; in vitro it reduces glutamate dysregulation and neuron hyperactivity.

Technical Data for NFAT inhibitor, Cell Permeable

M. Wt	3573.15
Formula	C₁₄₇H₂₅₉N₆₇O₃₆S
Single Letter Sequence	RRRRRRRRRRRGGGMAGPHPVIVITGPHEE
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	592517-80-1
PubChem ID	16140839
InChi Key	VNTCWMOQGXMIQP-PIQGMSCVSA-N
Smiles	[H]N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NFAT inhibitor, Cell Permeable

Solubility

Soluble to 1mg/ml in water

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References for NFAT inhibitor, Cell Permeable

References are publications that support the biological activity of the product.

Sompol Calcineurin/NFAT signaling in activated astrocytes drives network hyperexcitability in Aβ-bearing mice. J.Neurosci. 2017 PMID: 28559377
Noguchi A new cell-permeable peptide allows successful allogeneic islet transplantation in mice. Nat.Med. 2004 PMID: 14770176
Lee Function and therapeutic value of astrocytes in neurological diseases. Nat.Rev.Drug Discov. 2022 PMID: 35173313
Elloumi A cell permeable peptide inhibitor of NFAT inhibits macrophage cytokine expression and ameliorates experimental colitis. PLoS One 2012 PMID: 22479554