Neuropeptide FF

Name: Neuropeptide FF
Brand: Tocris Bioscience
SKU: 3137

Tocris Bioscience, part of Bio-Techne | Catalog # 3137

Citations (10)

COA / SDS

Endogenous NPFF1 and NPFF2 agonist; also MRGPRA agonist

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Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices

Key Product Details

Description

Endogenous NPFF1 and NPFF2 agonist; also MRGPRA agonist

View all Neuropeptide FF/AF Receptor Agonists »

Product Description

Neuropeptide FF is an endogenous antiopioid peptide and agonist at NPFF₁ and NPFF₂ receptors (K_i values are 2.82 and 0.21 nM respectively). Exhibits anorexigenic effects following i.c.v. administration. Also MRGPRA agonist.

Product Specifications

Molecular Weight

1081.28

Formula

C₅₄H₇₆N₁₄O₁₀

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

99566-27-5

PubChem ID

9854861

InChI Key

HWYCFZUSOBOBIN-AQJXLSMYSA-N

SMILES

[H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 0.5mg/ml in water

Calculators

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Reconstitution Calculator

Background References

References are publications that support the biological activity of the product.

Gouarderes Functional differences between NPFF₁ and NPFF₂ receptor coupling: high intrinsic activities of RFamide-related peptides on stimulation of[³⁵S]GTPγS binding. Neuropharmacology 2007 PMID: 17011599
Solinski Pharmacology and signaling of MAS-related G protein-coupled receptors. Pharmacol.Rev. 2014 PMID: 24867890
Cline Central neuropeptide FF reduces feed consumption and affects hypothalamic chemistry in chicks. Neuropeptides 2007 PMID: 17936900