Nelfinavir mesylate
Tocris Bioscience, part of Bio-Techne | Catalog # 3766
Potent HIV-1 protease inhibitor
Key Product Details
Description
Potent HIV-1 protease inhibitor
Alternative Names
AG 1341
Product Description
Nelfinavir mesylate is an orally active human immunodeficiency virus protease inhibitor. Potently inhibits HIV-1 protease (Ki = 2 nM) in vitro. Also exhibits anti-MERS-CoV activity in Vero cells in vitro (IC50 = 0.08 μM).Licensing Information
Sold for research purposes under agreement from Pfizer Inc.Product Specifications
Molecular Weight
663.89
Formula
C32H45N3O4S.CH4O3S
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
(3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2- hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide methanesulfonate
CAS Number
159989-65-8
PubChem ID
64142
InChI Key
NQHXCOAXSHGTIA-SKXNDZRYSA-N
SMILES
[H][C@]12CCCC[C@]([H])1C[C@@H]([C@@](NC(C)(C)C)=O)N(C[C@@H](O)[C@H](CSC3=CC=CC=C3)NC(C4=C(C)C(O)=CC=C4)=O)C2.CS(=O)(O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 66.39 | 100 | |
| Ethanol | 66.39 | 100 |
Preparing Stock Solutions
for Nelfinavir mesylate
The following data is based on the product molecular weight 663.89
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.51 mL | 7.53 mL | 15.06 mL |
| 5 mM | 0.30 mL | 1.51 mL | 3.01 mL |
| 10 mM | 0.15 mL | 0.75 mL | 1.51 mL |
| 50 mM | 0.03 mL | 0.15 mL | 0.30 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ko Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19. Viruses 2021 PMID: 33918958
- Musarrat The anti-HIV drug nelfinavir mesylate (Viracept) is a potent inhibitor of cell fusion caused by the SARSCoV-2 spike (S) glycoprotein warranting further evaluation as an antiviral against COVID-19 infections. J.Med.Virol. 2020 PMID: 32374457
- Patick Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease. Antimicrob.Agents Chemother. 1996 PMID: 8787874
- Gills Nelfinavir, a lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy and apoptosis in vitro and in vivo. Clin.Cancer Res.
- Shetty Preclinical pharmacokinetics and distribution to tissue of AG1343, an inhibitor of human immunodeficiency virus type 1 protease. Antimicrob.Agents Chemother. 1996 PMID: 8787890
Product Specific Notices for Nelfinavir mesylate
For research use only
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