Necrostatin-1

Tocris Bioscience, part of Bio-Techne | Catalog # 2324

RIP1 kinase inhibitor; inhibits necroptosis
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Key Product Details

Description

RIP1 kinase inhibitor; inhibits necroptosis

View all RIP Kinase Inhibitors »

Product Description

Necrostatin-1 is an ATP-competitive, allosteric inhibitor of receptor-interacting protein kinase 1 (RIPK1) (EC50 = 182 nM). Blocks non-apoptotic cell death via inhibition of a specific cellular pathway, necroptosis, which leads to necrosis (EC50 = 494 nM). Reduces ischemic brain injury in a mouse model of stroke.

Product Specifications

Molecular Weight

259.33

Formula

C13H13N3OS

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone

CAS Number

4311-88-0

PubChem ID

2828334

InChI Key

TXUWMXQFNYDOEZ-UHFFFAOYSA-N

SMILES

CN1C(=S)NC(CC2=CNC3=CC=CC=C23)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 7.78 30

Preparing Stock Solutions for Necrostatin-1

The following data is based on the product molecular weight 259.33

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.3 mM 12.85 mL 64.27 mL 128.54 mL
1.5 mM 2.57 mL 12.85 mL 25.71 mL
3 mM 1.29 mL 6.43 mL 12.85 mL
15 mM 0.26 mL 1.29 mL 2.57 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for Necrostatin-1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Necrostatin-1

For research use only

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