Key Product Details
Description: | RIP1 kinase inhibitor; inhibits necroptosis |
Chemical Name: | 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone |
Purity: | ≥98% (HPLC) |
Molecular Weight: | 259.33 |
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Citations for Necrostatin-1 (4)
Citations are publications that use Bio-Techne products. Selected citations for Necrostatin-1 include:
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Chefetz et al.
(2019)
A Pan-ALDH1A Inhibitor Induces Necroptosis in Ovarian Cancer Stem-like Cells.
Cell Rep.
26:3061
PMID: 30865894 -
Greer et al.
(2018)
ONC201 kills breast cancer cells in vitro by targeting mitochondria.
Oncotarget.
9:18454
PMID: 29719618 -
Kim
(2017)
Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells
Journal of Translational Medicine.
15(1):123
PMID: 28569199 -
Sagher et al.
(2014)
The small molecule NSC676914A is cytotoxic and differentially affects NFκB signaling in ovarian cancer cells and HEK293 cells.
Cancer Cell Int.
14:75
PMID: 25324692
There are no citations that match your criteria.
Customer Reviews for Necrostatin-1 (2)
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Species: HumanAssay Type: In VitroCombinatorial treatments of Necrostatin-1 with other chemotherapeutic drugs were performed to elucidate the dependance of the latter on the induction of necroptosis. Results were consistent.
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Species: HumanAssay Type: In VitroCell Line/Tissue: Caco-2100nM of Nec-1 was used to inhibit RIPK1 after administration cells with TNFa, zVADfmk, and smac inhibitors to induce necroptosis, then cell death rate was measured with a commercial kit.
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