NE 100 hydrochloride

Name: NE 100 hydrochloride
Brand: Tocris Bioscience
SKU: 3133
Rating: 3 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 3133

Citations (7)

(1)

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Key Product Details

Description:	Selective σ₁ antagonist
Chemical Name:	4-Methoxy-3-(2-phenylethoxy)-N,N-dipropylbenzeneethanamine hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	391.97

View Full Technical Details for NE 100 hydrochloride

Biological Activity for NE 100 hydrochloride

NE 100 hydrochloride is a potent and selective σ₁ receptor antagonist (K_i = 0.86 nM) that displays > 55-fold selectivity over σ₂ receptors and > 6000-fold selectivity over D₁, D₂, 5-HT_1A, 5-HT₂ and PCP receptors. Exhibits reversible binding (K_d = 1.2 nM) and displays antipsychotic activity in vivo. Orally active.

Compound Libraries for NE 100 hydrochloride

NE 100 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for NE 100 hydrochloride

M. Wt	391.97
Formula	C₂₃H₃₃NO₂.HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	149409-57-4
PubChem ID	9952420
InChi Key	ZHGMDXSHODHWHV-UHFFFAOYSA-N
Smiles	CCCN(CCC)CCC1=CC=C(OC)C(OCCC2=CC=CC=C2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NE 100 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	9.8	25
	DMSO	39.2	100

Preparing Stock Solutions for NE 100 hydrochloride

The following data is based on the product molecular weight 391.97.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.55 mL	12.76 mL	25.51 mL
5 mM	0.51 mL	2.55 mL	5.10 mL
10 mM	0.26 mL	1.28 mL	2.55 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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References for NE 100 hydrochloride

References are publications that support the biological activity of the product.

Tanaka Characteristics of binding of [³H]NE-100, a novel sigma-receptor ligand, to guinea-pig brain membranes. Naunyn Schmied.Arch.Pharmacol.
Chaki NE-100, a novel potent σ ligand, preferentially binds to σ1 binding sites in guinea pig brain. Eur.J.Pharmacol. 1994 PMID: 8137864
Okuyama NE-100, a novel sigma receptor ligand: in vivo tests. Pharmacol.Letts.

Citations for NE 100 hydrochloride (7)

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Citations are publications that use Bio-Techne products. Selected citations for NE 100 hydrochloride include:

Song et al. (2022) Sigma non-opioid receptor 1 is a potential therapeutic target for long QT syndrome. Nat.Card.Res.. 1:142
PMID: 36051854
Atzmon et al. (2018) Drug Screening Identifies Sigma-1-Receptor as a Target for the Therapy of VWM Leukodystrophy. Front Mol Neurosci. 11:336
PMID: 30279648
Maurice (2017) Amyloid toxicity is enhanced after pharmacological or genetic invalidation of the σ1 receptor. Behav Brain Res. 339:1
PMID: 29129596
Rodríguez-Muñoz et al. (2015) The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders. Br J Pharmacol. 6:35458
PMID: 26461475
Malik et al. (2015) The effects of σ (σ1) receptor-selective ligands on muscarinic receptor antagonist-induced cognitive deficits in mice. Int J Neuropsychopharmacol. 172:2519
PMID: 25573298
Sánchez-Blázquez et al. (2014) The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases. Eur J Immunol. 17:1943
PMID: 24485144
Fishback et al. (2012) A 96-well filtration method for radioligand binding analysis of σ receptor ligands. J Pharm Biomed Anal. 71:157
PMID: 22910107

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Customer Reviews for NE 100 hydrochloride (1)

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It can inhibit sigma1 receptor

Name: Yuyang Sun

Species: Human

Assay Type: In Vitro

Cell Line/Tissue: sh-sy5y

Used it to inhibit sigma 1 receptors. It can inhibit sigma 1 receptor and increase SOCE channels.

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Product Documents for NE 100 hydrochloride

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.