NCL 00017509
Tocris Bioscience, part of Bio-Techne | Catalog # 5150
Potent and reversible NIMA related kinase 2 (Nek2) inhibitor
Key Product Details
Description
Potent and reversible NIMA related kinase 2 (Nek2) inhibitor
Product Description
NCL 00017509 is a potent and reversible NIMA related kinase 2 (Nek2) inhibitor (IC50 = 56 nM). Induces increased mitotic abnormalities and mitotic delay. Cell permeable and active in vivo. In mice bearing pancreatic tumors, NCL 00017509 decreases PD-L1 expression and induces an anticancer immune response.Product Specifications
Molecular Weight
292.30
Formula
C15H12N6O
Storage
Store at -20°C
Purity
≥97% (HPLC)
Chemical Name
3-[(6-Ethynyl-9H-purin-2-yl)amino]benzeneacetamide
CAS Number
1507367-00-1
PubChem ID
56944360
InChI Key
CJQGLUJHMXCLQY-UHFFFAOYSA-N
SMILES
C#CC1=C2C(NC=N2)=NC(NC3=CC=CC(CC(N)=O)=C3)=N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 29.23 | 100 |
Preparing Stock Solutions
for NCL 00017509
The following data is based on the product molecular weight 292.30
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.42 mL | 17.11 mL | 34.21 mL |
| 5 mM | 0.68 mL | 3.42 mL | 6.84 mL |
| 10 mM | 0.34 mL | 1.71 mL | 3.42 mL |
| 50 mM | 0.07 mL | 0.34 mL | 0.68 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Zhang NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1. Nat.Commun. 2021 PMID: 34315872
- Lebraud Model system for irreversible inhibition of Nek2: thiol addition to ethynylpurines and related substituted heterocycles. Org.Biomol.Chem. 2014 PMID: 24213855
Product Specific Notices for NCL 00017509
For research use only
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