NAN-190 hydrobromide

Name: NAN-190 hydrobromide
Brand: tocris
SKU: 0553

Catalog # 0553

Citations (3)

Datasheet / COA / SDS

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Key Product Details

Description:	5-HT_1A antagonist
Chemical Name:	1-(2-Methoxyphenyl)-4-(4-phthalimidobutyl)piperazine hydrobromide
Purity:	≥98% (HPLC)
Molecular Weight:	474.4

View Full Technical Details for NAN-190 hydrobromide

Biological Activity

5-HT_1A antagonist.

Technical Data

M. Wt	474.4
Formula	C₂₃H₂₇N₃O₃.HBr
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	115338-32-4
PubChem ID	107966
InChi Key	AXRUEPFPTQYHQD-UHFFFAOYSA-N
Smiles	Br.COC1=C(C=CC=C1)N1CCN(CCCCN2C(=O)C3=CC=CC=C3C2=O)CC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	4.74	10

Preparing Stock Solutions

The following data is based on the product molecular weight 474.4.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.08 mL	105.40 mL	210.79 mL
0.5 mM	4.22 mL	21.08 mL	42.16 mL
1 mM	2.11 mL	10.54 mL	21.08 mL
5 mM	0.42 mL	2.11 mL	4.22 mL

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References

References are publications that support the biological activity of the product.

Douris Effects of the putative 5-HT_1A receptor antagonist NAN-190 on free feeding and on feeding induced by the 5-HT_1A receptor agonist 8-OH-DPAT in the rat. Eur.J.Pharmacol. 1992 PMID: 1397037
Glennon Arylpiperazine derivatives as high affinity 5-HT_1A serotonin ligands. J.Med.Chem. 1988 PMID: 3172131
Williams and Glennon NAN-190: an arylpiperazine analog that antagonizes the stimulus effects of the 5-HT_1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Eur.J.Pharmacol. 1988 PMID: 2976673

Citations (3)

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Citations are publications that use Bio-Techne products. Selected citations for NAN-190 hydrobromide include:

Demarque and (2010) Activity-dependent expression of Lmx1b regulates specification of serotonergic neurons modulating swimming behavior. Neuron. 67:321
PMID: 20670838
Pagano et al. (2008) Gαo/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways. Physiol Behav. 20:1190
PMID: 18407463
Geerts et al. (1999) Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery. Br J Pharmacol. 127:1327
PMID: 10455282

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Product Datasheets

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Certificate of Analysis

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NAN-190 hydrobromide

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References

Citations (3)

Product Datasheets

COA

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