Nafamostat mesylate

Name: Nafamostat mesylate
Brand: Tocris Bioscience
SKU: 3081
Rating: 3 (1 reviews)

Tocris Bioscience, part of Bio-Techne | Catalog # 3081

(1)

Citations (19)

COA / SDS

Serine protease inhibitor; inhibits tryptase

Key Product Details

Description:	Serine protease inhibitor; inhibits tryptase
Chemical Name:	4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester dimethanesulfonate
Purity:	≥98% (HPLC)
Molecular Weight:	539.59

View Full Technical Details for Nafamostat mesylate

Technical Data
Citations / Reviews (1)

Biological Activity for Nafamostat mesylate

Nafamostat mesylate is a broad spectrum serine protease inhibitor. Displays selectivity for human tryptase when used at relatively low concentrations. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma. Inhibits SARS-CoV-2 infection in vitro (EC₅₀ = 22.50 μM).

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

Compound Libraries for Nafamostat mesylate

Nafamostat mesylate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for Nafamostat mesylate

M. Wt	539.59
Formula	C₁₉H₁₇N₅O₂.2CH₄O₃S
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	82956-11-4
PubChem ID	54953
InChi Key	SRXKIZXIRHMPFW-UHFFFAOYSA-N
Smiles	CS(=O)(O)=O.NC(C1=CC=C2C(C=CC(OC(C3=CC=C(NC(N)=N)C=C3)=O)=C2)=C1)=N.CS(=O)(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Nafamostat mesylate

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	53.96	100
	DMSO	53.96	100

Preparing Stock Solutions for Nafamostat mesylate

The following data is based on the product molecular weight 539.59.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.85 mL	9.27 mL	18.53 mL
5 mM	0.37 mL	1.85 mL	3.71 mL
10 mM	0.19 mL	0.93 mL	1.85 mL
50 mM	0.04 mL	0.19 mL	0.37 mL

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References for Nafamostat mesylate

References are publications that support the biological activity of the product.

Wang Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Research 2020 PMID: 32020029
Sendo A potent tryptase inhibitor nafamostat mesilate dramatically suppressed pulmonary dysfunction induced in rats by a radiographic contrast medium. Br.J.Pharmacol. 2003 PMID: 12642398
Chen Serine protease inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen-induced airway inflammation and eosinophilia in a murine model of asthma. J.Allergy Clin.Immunol. 2006 PMID: 16815145
Mori Nafamostat mesilate is an extremely potent inhibitor of human tryptase. J.Pharmacol.Sci. 2003 PMID: 12939527