NAB 2

Name: NAB 2
Brand: Tocris Bioscience
SKU: 5131

Tocris Bioscience, part of Bio-Techne | Catalog # 5131

Citations (3)

COA / SDS

Protects against α-synuclein toxicity; promotes Rsp5/Nedd4-dependent endosomal transport

Discontinued Product

5131 has been discontinued. View all Ubiquitin Ligase (E3) Inhibitors products.

Key Product Details

Description:	Protects against α-synuclein toxicity; promotes Rsp5/Nedd4-dependent endosomal transport
Chemical Name:	N-[(2-Chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-1H-benzimidazole-5-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	389.88

View Full Technical Details for NAB 2

Technical Data
Citations

Biological Activity for NAB 2

NAB 2 protects against α-synuclein toxicity. NAB 2 reverses the α-synuclein-induced pathological phenotype in Parkinson's disease cortical neurons. NAB 2 promotes E3 ubiquitin ligase Rsp5/Nedd4-dependent endosomal transport.

Licensing Information

Sold under license from Whitehead Institute for Biomedical Research.

Technical Data for NAB 2

M. Wt	389.88
Formula	C₂₃H₂₀ClN₃O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1504588-00-4
PubChem ID	82017756
InChi Key	CZSLEMCYYGEGKP-UHFFFAOYSA-N
Smiles	O=C(NCC4=C(Cl)C=CC=C4)C1=CC=C2C(N=CN2C3=CC(C)=CC=C3C)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for NAB 2

References are publications that support the biological activity of the product.

Chung Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science 2013 PMID: 24158904
Hatstat Characterization of small-molecule-induced changes in Parkinson's-related trafficking via the Nedd4 ubiquitin signaling cascade. Cell Chem.Biol. 2021 PMID: 33176158
Tardiff Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science 2013 PMID: 24158909