NAADP tetrasodium salt

Name: NAADP tetrasodium salt
Brand: Tocris Bioscience
SKU: 3905

Tocris Bioscience a Bio-Techne Brand

Catalog # 3905

Citations (3)

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Key Product Details

Description:	Ca²⁺ mobilizing agent
Alternative Names:	NAADP
Chemical Name:	Nicotinic acid adenine dinucleotide phosphate tetrasodium salt
Purity:	≥98% (HPLC)
Molecular Weight:	832.32

View Full Technical Details for NAADP tetrasodium salt

Biological Activity for NAADP tetrasodium salt

NAADP tetrasodium salt is a Ca²⁺ mobilizing agent. Initiates Ca²⁺ release via type 1 ryanodine receptor (RyR1) activation. Also regulates Ca²⁺ release from intracellular stores distinct from the endoplasmic reticulum (ER); displays affinity for two-pore channels (TPCs) which release Ca²⁺ from acidic organelles.

Technical Data for NAADP tetrasodium salt

M. Wt	832.32
Formula	C₂₁H₂₃N₆Na₄O₁₈P₃
Storage	Store at -20°C
Purity	≥98% (HPLC)
PubChem ID	90488897
InChi Key	NWKIGVGTZIAOCW-MCNGMCCKSA-J
Smiles	[Na+].[Na+].[Na+].[Na+].NC1=C2N=CN([C@@H]3O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]4O[C@H]([C@H](O)[C@@H]4O)[N+]4=CC(=CC=C4)C([O-])=O)[C@@H](O)[C@H]3OP([O-])([O-])=O)C2=NC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for NAADP tetrasodium salt

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	41.62	50

Preparing Stock Solutions for NAADP tetrasodium salt

The following data is based on the product molecular weight 832.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.40 mL	12.01 mL	24.03 mL
2.5 mM	0.48 mL	2.40 mL	4.81 mL
5 mM	0.24 mL	1.20 mL	2.40 mL
25 mM	0.05 mL	0.24 mL	0.48 mL

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References for NAADP tetrasodium salt

References are publications that support the biological activity of the product.

Calcraft NAADP mobilizes calcium from acidic organelles through two-pore channels. Nature 2009 PMID: 19387438
Dammerman NAADP-mediated Ca²⁺ signaling via type 1 ryanodine receptor in T cells revealed by a synthetic NAADP agonist. Proc.Natl.Acad.Sci.
Galion NAADP, a new intracellular messenger that mobilizes Ca²⁺ from acidic stores. Biochem.Soc.Transactions

Citations for NAADP tetrasodium salt (3)

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Citations are publications that use Bio-Techne products. Selected citations for NAADP tetrasodium salt include:

Hadi et al. (2018) Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells. Nat Commun. 9:5022
PMID: 30479344
Ruas et al. (2015) Expression of Ca2+-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells. Am J Physiol Gastrointest Liver Physiol. NULL
PMID: 25872774
Wang et al. (2012) TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes. Cell. 151:372
PMID: 23063126

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