N-Nonyldeoxynojirimycin

Name: N -Nonyldeoxynojirimycin
Brand: Tocris Bioscience
SKU: 3691

Tocris Bioscience a Bio-Techne Brand

Catalog # 3691

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Key Product Details

Description:	Glucosidase inhibitor
Alternative Names:	NN-DNJ
Chemical Name:	(2R,3R,4R,5S)-2-(Hydroxymethyl)-1-nonyl-3,4,5-piperidinetriol
Molecular Weight:	289.41

View Full Technical Details for N-Nonyldeoxynojirimycin

Biological Activity for N-Nonyldeoxynojirimycin

N-Nonyldeoxynojirimycin is a glucosidase inhibitor (IC₅₀ values are 0.42 and 8.4 μM for acid α-glucosidase and α-1,6-glucosidase respectively). Inhibits liver glycogen breakdown in vivo. Also acts as a chemical chaperone; chaperones β-Glu folding at neutral p.H. allowing the stabilized enzyme to transit from the endoplasmic reticulum to the golgi, enabling proper trafficking to the lysosome.

Technical Data for N-Nonyldeoxynojirimycin

M. Wt	289.41
Formula	C₁₅H₃₁NO₄
Storage	Store at -20°C
CAS Number	81117-35-3
PubChem ID	501640
InChi Key	FTSCEGKYKXESFF-LXTVHRRPSA-N
Smiles	O[C@H]1[C@H](O)[C@@H](CO)N(CCCCCCCCC)C[C@@H]1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for N-Nonyldeoxynojirimycin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	28.94	100
	ethanol	28.94	100

Preparing Stock Solutions for N-Nonyldeoxynojirimycin

The following data is based on the product molecular weight 289.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.46 mL	17.28 mL	34.55 mL
5 mM	0.69 mL	3.46 mL	6.91 mL
10 mM	0.35 mL	1.73 mL	3.46 mL
50 mM	0.07 mL	0.35 mL	0.69 mL

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References for N-Nonyldeoxynojirimycin

References are publications that support the biological activity of the product.

Andersson Inhibition of glycogen breakdown by imino sugars in vitro and in vivo. Biochem.Pharmacol. 2004 PMID: 14757169
Mellor Cellular effects of deoxyojirimycin analogues: inhibition of N-linked oligosaccharide processing and generation of free glucosylated oligosaccharides. Biochem.J. 2004 PMID: 15128289
Sawkar Chemical chaperones increase the cellular activity of N307S β-glucosidase: a therapeutic strategy for Gaucher disease. Proc.Natl.Acad.Sci.USA

Citations for N-Nonyldeoxynojirimycin

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