N-Acetylpuromycin
Tocris Bioscience, part of Bio-Techne | Catalog # 5679
Downregulates SnoN and Ski protein expression; promotes TGF-β signaling
Key Product Details
Description
Downregulates SnoN and Ski protein expression; promotes TGF-β signaling
Product Description
N-Acetylpuromycin downregulates SnoN and Ski protein expression; promotes TGF-β signaling, independently of MAPK activation. Does not bind ribosomes or block protein synthesis.Product Specifications
Molecular Weight
513.55
Formula
C24H31N7O6
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
3'-[[(2S)-2-(Acetylamino)-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyladenosine
CAS Number
22852-13-7
PubChem ID
46173769
InChI Key
LADKVYSQIGJMFP-IYRMOJGWSA-N
SMILES
O[C@@H]1[C@H](NC([C@@H](NC(C)=O)CC4=CC=C(OC)C=C4)=O)[C@@H](CO)O[C@H]1N3C2=NC=NC(N(C)C)=C2N=C3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 51.35 | 100 | |
| DMSO | 51.35 | 100 |
Preparing Stock Solutions
for N-Acetylpuromycin
The following data is based on the product molecular weight 513.55
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.95 mL | 9.74 mL | 19.47 mL |
| 5 mM | 0.39 mL | 1.95 mL | 3.89 mL |
| 10 mM | 0.19 mL | 0.97 mL | 1.95 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.39 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hernández-Damián Downregulation of SnoN oncoprotein induced by antibiotics anisomycin and puromycin positively regulates transforming growth factor-β signals. Biochim.Biophys.Acta. 2013 PMID: 23872350
Product Specific Notices for N-Acetylpuromycin
For research use only
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