N-Acetyl-L-leucyl-L-leucyl-L-methional
Tocris Bioscience, part of Bio-Techne | Catalog # 0384
Cathepsin inhibitor
Discontinued Product
0384 has been discontinued.
An alternative/replacement product is available:
4545. View all Synthetic Cathepsin Inhibitors products.
Product Description
Very potent inhibitor of cathepsin L (Ki = 0.6 nM) and the strongest inhibitor of cathepsin B (Ki = 100 nM) amongst the peptide aldehydes. Also inhibits processing of malaria aspartic hemoglobinases plasmepsins I and II in vitro.Product Specifications
Molecular Weight
401.56
Formula
C19H35N3O4S
Storage
Store at -20°C
CAS Number
145757-50-2
PubChem ID
4331
InChI Key
RJWLAIMXRBDUMH-UHFFFAOYSA-N
SMILES
O=C(C)NC(C(NC(C(NC(C([H])=O)CCSC)=O)CC(C)C)=O)CC(C)C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.16 | 100 | |
| Ethanol | 4.02 | 10 |
Preparing Stock Solutions
for N-Acetyl-L-leucyl-L-leucyl-L-methional
The following data is based on the product molecular weight 401.56
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.49 mL | 12.45 mL | 24.90 mL |
| 5 mM | 0.50 mL | 2.49 mL | 4.98 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.49 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.50 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sasaki Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins. J.Enzyme Inhib. 1990 PMID: 2079636
- Francis Biosynthesis and maturation of the malaria aspartic hemogloninases plasmepsins I and II. J.Biol.Chem. 1997 PMID: 9169469
Product Specific Notices for N-Acetyl-L-leucyl-L-leucyl-L-methional
For research use only
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