N-Acetyl-L-leucyl-L-leucyl-L-methional

Name: N -Acetyl-L-leucyl-L-leucyl-L-methional
Brand: tocris
SKU: 0384

Catalog # 0384

Datasheet / COA / SDS

Discontinued Product

0384 has been discontinued and is replaced by 4545.

Order Information

Bio-Techne Corporation

tel: (612) 379-2956

tel: (800) 343-7475 (free phone)

customercare.na@bio-techne.com

Shipping Information

$35 to United States

Products in stock will be shipped in 1-3 business days unless specified.

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Key Product Details

Description:

Cathepsin inhibitor

View Full Technical Details for N-Acetyl-L-leucyl-L-leucyl-L-methional

Biological Activity

Very potent inhibitor of cathepsin L (K_i = 0.6 nM) and the strongest inhibitor of cathepsin B (K_i = 100 nM) amongst the peptide aldehydes. Also inhibits processing of malaria aspartic hemoglobinases plasmepsins I and II in vitro.

Technical Data

M. Wt	401.56
Formula	C₁₉H₃₅N₃O₄S
Storage	Store at -20°C
CAS Number	145757-50-2
PubChem ID	4331
InChi Key	RJWLAIMXRBDUMH-UHFFFAOYSA-N
Smiles	O=C(C)NC(C(NC(C(NC(C([H])=O)CCSC)=O)CC(C)C)=O)CC(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	4.02	10
	DMSO	40.16	100

Preparing Stock Solutions

The following data is based on the product molecular weight 401.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.49 mL	12.45 mL	24.90 mL
5 mM	0.50 mL	2.49 mL	4.98 mL
10 mM	0.25 mL	1.25 mL	2.49 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

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Reconstitution Calculator

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References

References are publications that support the biological activity of the product.

Francis Biosynthesis and maturation of the malaria aspartic hemogloninases plasmepsins I and II. J.Biol.Chem. 1997 PMID: 9169469
Sasaki Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins. J.Enzyme Inhib. 1990 PMID: 2079636