N-Acetyl-L-leucyl-L-leucyl-L-methional

Name: N -Acetyl-L-leucyl-L-leucyl-L-methional
Brand: Tocris Bioscience
SKU: 0384

Tocris Bioscience, part of Bio-Techne | Catalog # 0384

COA / SDS

New Version Available - 4545

Cathepsin inhibitor

Discontinued Product

0384 has been discontinued. An alternative/replacement product is available: 4545. View all Synthetic Cathepsin Inhibitors products.

Key Product Details

Description:	Cathepsin inhibitor
Molecular Weight:	401.56

View Full Technical Details for N-Acetyl-L-leucyl-L-leucyl-L-methional

Technical Data
Citations

Biological Activity for N-Acetyl-L-leucyl-L-leucyl-L-methional

Very potent inhibitor of cathepsin L (K_i = 0.6 nM) and the strongest inhibitor of cathepsin B (K_i = 100 nM) amongst the peptide aldehydes. Also inhibits processing of malaria aspartic hemoglobinases plasmepsins I and II in vitro.

Technical Data for N-Acetyl-L-leucyl-L-leucyl-L-methional

M. Wt	401.56
Formula	C₁₉H₃₅N₃O₄S
Storage	Store at -20°C
CAS Number	145757-50-2
PubChem ID	4331
InChi Key	RJWLAIMXRBDUMH-UHFFFAOYSA-N
Smiles	O=C(C)NC(C(NC(C(NC(C([H])=O)CCSC)=O)CC(C)C)=O)CC(C)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for N-Acetyl-L-leucyl-L-leucyl-L-methional

References are publications that support the biological activity of the product.

Sasaki Inhibitory effect of di- and tripeptidyl aldehydes on calpains and cathepsins. J.Enzyme Inhib. 1990 PMID: 2079636
Francis Biosynthesis and maturation of the malaria aspartic hemogloninases plasmepsins I and II. J.Biol.Chem. 1997 PMID: 9169469

N-Acetyl-L-leucyl-L-leucyl-L-methional

Tocris Bioscience, part of Bio-Techne | Catalog # 0384

Key Product Details

Biological Activity for N-Acetyl-L-leucyl-L-leucyl-L-methional

Technical Data for N-Acetyl-L-leucyl-L-leucyl-L-methional

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for N-Acetyl-L-leucyl-L-leucyl-L-methional

Product Documents for N-Acetyl-L-leucyl-L-leucyl-L-methional

COA

Certificate of Analysis

SDS

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