MYX 1715
Tocris Bioscience, part of Bio-Techne | Catalog # 8109
N-myristoyltransferase (NMT) inhibitor
Key Product Details
Description
N-myristoyltransferase (NMT) inhibitor
Product Description
MYX 1715 is a N-myristoyltransferase inhibitor (NMT). MYX 1715 selectively kills senescent cancer cells in mouse models of paediatric pituitary tumors and liver cancer, and prevents tumor growth in mouse xenografts. In mouse models of idiopathic pulmonary fibrosis (IPF) and NASH, MYX 1715 reduces both lung and liver fibrosis, and decreases inflammation and steatosis.Product Specifications
Molecular Weight
553.91
Formula
C25H29ClN6O2.2HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
4-[2-[2-[3-(2-Aminoethyl)imidazo[1,2-a]pyridin-6-yl]-5-chlorophenoxy]ethyl]-N,N,1,5-tetramethyl-1H-pyrazole-3-carboxamide dihydrochloride
InChI Key
IPOQBMAKZNXYNK-UHFFFAOYSA-N
SMILES
O=C(N(C)C)C1=NN(C)C(C)=C1CCOC2=C(C3=CN4C(CCN)=CN=C4C=C3)C=CC(Cl)=C2.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 55.39 | 100 | |
| DMSO | 55.39 | 100 |
Preparing Stock Solutions
for MYX 1715
The following data is based on the product molecular weight 553.91
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.81 mL | 9.03 mL | 18.05 mL |
| 5 mM | 0.36 mL | 1.81 mL | 3.61 mL |
| 10 mM | 0.18 mL | 0.90 mL | 1.81 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- McHugh COPI vesicle formation and N-myristoylation are targetable vulnerabilities of senescent cells. Nat.Cell Biol. 2023 PMID: 38012402
Product Specific Notices for MYX 1715
For research use only
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