MSOP

Tocris Bioscience, part of Bio-Techne | Catalog # 0803

COA / SDS

Specific group III mGlu antagonist

Key Product Details

Description:	Specific group III mGlu antagonist
Chemical Name:	(RS)-α-Methylserine-O-phosphate
Molecular Weight:	199.1

View Full Technical Details for MSOP

Technical Data
Citations

Biological Activity for MSOP

MSOP is a selective group III metabotropic glutamate receptor antagonist. Displays an apparent K_D of 51 μM for the L-AP4-sensitive presynaptic mGluR on primary afferent terminals in spinal cord compared to > 700 μM for the (1S,3S)-ACPD-sensitive presynaptic mGlu in the same system. Has no activity on postsynaptic mGlu receptors or on ionotropic glutamate receptors on neonatal rat motoneurons.

Technical Data for MSOP

M. Wt	199.1
Formula	C₄H₁₀NO₆P
Storage	Store at RT
CAS Number	66515-29-5
PubChem ID	3964633
InChi Key	GSFCOAGADOGIGE-UHFFFAOYSA-N
Smiles	NC(COP(O)(O)=O)(C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MSOP

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	19.91	100

Preparing Stock Solutions for MSOP

The following data is based on the product molecular weight 199.1.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.02 mL	25.11 mL	50.23 mL
5 mM	1.00 mL	5.02 mL	10.05 mL
10 mM	0.50 mL	2.51 mL	5.02 mL
50 mM	0.10 mL	0.50 mL	1.00 mL

Molarity Calculator

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Reconstitution Calculator

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References for MSOP

References are publications that support the biological activity of the product.

Jane Phosphono substituted amino acids as selective metabotropic glutamate receptor antagonists. Phosphorous, Sulphur and Silicon
Thomas Serine-O-phosphate derivatives as novel, potent and selective metabotropic glutamate receptor (mGluR) antagonists. Soc.Neurosci.Abstr.
Thomas α-Methyl derivatives of serine-O-phosphate as novel, selective competitive metabotropic glutamate receptor antagonists. Neuropharmacology 1996 PMID: 8887973