MSOP

Tocris Bioscience a Bio-Techne Brand

Catalog # 0803

Citations (7)

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Key Product Details

Description:	Specific group III mGlu antagonist
Chemical Name:	(RS)-α-Methylserine-O-phosphate
Molecular Weight:	199.1

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Biological Activity for MSOP

MSOP is a selective group III metabotropic glutamate receptor antagonist. Displays an apparent K_D of 51 μM for the L-AP4-sensitive presynaptic mGluR on primary afferent terminals in spinal cord compared to > 700 μM for the (1S,3S)-ACPD-sensitive presynaptic mGlu in the same system. Has no activity on postsynaptic mGlu receptors or on ionotropic glutamate receptors on neonatal rat motoneurons.

Technical Data for MSOP

M. Wt	199.1
Formula	C₄H₁₀NO₆P
Storage	Store at RT
CAS Number	66515-29-5
PubChem ID	3964633
InChi Key	GSFCOAGADOGIGE-UHFFFAOYSA-N
Smiles	NC(COP(O)(O)=O)(C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MSOP

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	19.91	100

Preparing Stock Solutions for MSOP

The following data is based on the product molecular weight 199.1.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.02 mL	25.11 mL	50.23 mL
5 mM	1.00 mL	5.02 mL	10.05 mL
10 mM	0.50 mL	2.51 mL	5.02 mL
50 mM	0.10 mL	0.50 mL	1.00 mL

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References for MSOP

References are publications that support the biological activity of the product.

Thomas α-Methyl derivatives of serine-O-phosphate as novel, selective competitive metabotropic glutamate receptor antagonists. Neuropharmacology 1996 PMID: 8887973
Jane Phosphono substituted amino acids as selective metabotropic glutamate receptor antagonists. Phosphorous, Sulphur and Silicon
Thomas Serine-O-phosphate derivatives as novel, potent and selective metabotropic glutamate receptor (mGluR) antagonists. Soc.Neurosci.Abstr.

Citations for MSOP (7)

Showing 1 - 7 of 7 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for MSOP include:

Spaziano et al. (2015) Exposure to Allergen Causes Changes in NTS Neural Activities after Intratracheal Capsaicin Application, in Endocannabinoid Levels and in the Glia Morphology of NTS. Proc Natl Acad Sci U S A. 2015:980983
PMID: 25866824
Liu et al. (2013) Long-term potentiation of synaptic transmission in the adult mouse insular cortex: multielectrode array recordings. J Neurophysiol. 110:505
PMID: 23636718
Ster et al. (2011) Enhancement of CA3 hippocampal network activity by activation of group II metabotropic glutamate receptors. J Neurosci. 108:9993
PMID: 21628565
Derbenev et al. (2006) Vanilloid-mediated heterosynaptic facilitation of inhibitory synaptic input to neurons of the rat dorsal motor nucleus of the vagus. J Physiol. 26:9666
PMID: 16988037
Browning et al. (2006) Vagal afferent control of opioidergic effects in rat brainstem circuits. Biomed Res Int. 575:761
PMID: 16825311
Jiang et al. (2006) Activation of group III metabotropic glutamate receptors attenuates rotenone toxicity on DArgic neurons through a microtubule-dependent mechanism. J Neurosci. 26:4318
PMID: 16624952
Melyan et al. (2004) Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors. J Neurosci. 24:4530
PMID: 15140923

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