Selective group III metabotropic glutamate receptor antagonist. Displays an apparent KD of 51 μM for the L-AP4-sensitive presynaptic mGluR on primary afferent terminals in spinal cord compared to > 700 μM for the (1S,3S)-ACPD-sensitive presynaptic mGlu in the same system. Has no activity on postsynaptic mGlu receptors or on ionotropic glutamate receptors on neonatal rat motoneurons.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Max Conc. mg/mL
Max Conc. mM
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The following data is based on the product molecular weight 199.1.
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect
the solvent volumes required to prepare stock solutions.
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References are publications that support the biological activity of the product.