MS 6105
Tocris Bioscience, part of Bio-Techne | Catalog # 8073
Potent lactate dehydrogenase Degrader (PROTAC®)
Key Product Details
Description
Potent lactate dehydrogenase Degrader (PROTAC®)
Product Description
MS 6105 is a potent and selective lactate dehydrogenase (LDH) Degrader (PROTAC®; for LDHA and LDHB respectively, DC50 values are 38 nM and 74 nM; Dmax is 93% and 86%). Comprises an LDH inhibitor warhead connected by a linker to a VHL ligand. Suppresses growth of several pancreatic cancer cell lines (IC50 range is 12.2 μM - 16.1 μM). Bioavailable in vivo.PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Product Specifications
Molecular Weight
1228.60
Formula
C65H81N9O9S3
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
2-(5-(Cyclopropylmethyl)-3-(3-(6-(13-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-13-oxotridecanamido)hex-1-yn-1-yl)phenyl)-4-(4-sulfamoylbenzyl)-1H-pyrazol-1-yl)thiazole-4-carboxylic acid
CAS Number
2891709-58-1
PubChem ID
166642429
InChI Key
APEYSKGQWJKJAZ-LCLGPXMOSA-N
SMILES
O=C([C@@H](NC(CCCCCCCCCCCC(NCCCCC#CC1=CC=CC(C2=NN(C(CC3CC3)=C2CC4=CC=C(S(N)(=O)=O)C=C4)C5=NC(C(O)=O)=CS5)=C1)=O)=O)C(C)(C)C)N6[C@H](C(NCC7=CC=C(C=C7)C8=C(C)N=CS8)=O)C[C@@H](O)C6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 122.86 | 100 |
Preparing Stock Solutions
for MS 6105
The following data is based on the product molecular weight 1228.60
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.81 mL | 4.07 mL | 8.14 mL |
| 5 mM | 0.16 mL | 0.81 mL | 1.63 mL |
| 10 mM | 0.08 mL | 0.41 mL | 0.81 mL |
| 50 mM | 0.02 mL | 0.08 mL | 0.16 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sun Discovery of the first lactate dehydrogenase proteolysis targeting chimera degrader for the treatment of pancreatic cancer. J.Med.Chem. 2023 PMID: 36538511
Product Specific Notices for MS 6105
For research use only
Loading...
Loading...