MS 39N
Tocris Bioscience, part of Bio-Techne | Catalog # 7398
Negative control for MS 39 (Cat. No. 7397)
Key Product Details
Description
Negative control for MS 39 (Cat. No. 7397)
Product Description
MS 39N is a negative control for MS 39 (Cat. No. 7397). Binds EGFR without inducing degradation.Licensing Information
Sold under license from Icahn School of Medicine at Mount Sinai.Product Specifications
Molecular Weight
1056.74
Formula
C55H71ClFN9O7S
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
(2R,4S)-1-((S)-2-(11-(4-(3-((4-((3-Chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)propyl)piperazin-1-yl)-11-oxoundecanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS Number
2675490-96-5
PubChem ID
155565089
InChI Key
HLFLODKZIGYHNR-YFXVFWABSA-N
SMILES
COC1=CC2=NC=NC(NC3=CC(Cl)=C(C=C3)F)=C2C=C1OCCCN4CCN(CC4)C(CCCCCCCCCC(N[C@@H](C(C)(C)C)C(N5C[C@H](C[C@@H]5C(NCC6=CC=C(C=C6)C7=C(N=CS7)C)=O)O)=O)=O)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 105.67 | 100 |
Preparing Stock Solutions
for MS 39N
The following data is based on the product molecular weight 1056.74
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 0.95 mL | 4.73 mL | 9.46 mL |
| 5 mM | 0.19 mL | 0.95 mL | 1.89 mL |
| 10 mM | 0.09 mL | 0.47 mL | 0.95 mL |
| 50 mM | 0.02 mL | 0.09 mL | 0.19 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Cheng Discovery of potent and selective epidermal growth factor receptor (EGFR) bifunctional small-molecule degraders. J.Med.Chem. 2020 PMID: 31895569
Product Specific Notices for MS 39N
For research use only
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