MS 245 oxalate

Name: MS 245 oxalate
Brand: Tocris Bioscience
SKU: 4208

Tocris Bioscience, part of Bio-Techne | Catalog # 4208

COA / SDS

High affinity 5-HT6 antagonist

Discontinued Product

4208 has been discontinued. View all 5-HT6 Receptor Antagonists products.

Key Product Details

Description:	High affinity 5-HT₆ antagonist
Chemical Name:	5-Methoxy-N,N-dimethyl-1-(phenylsulfonyl)-1H-indole-3-ethanamine oxalate
Purity:	≥99% (HPLC)
Molecular Weight:	448.49

View Full Technical Details for MS 245 oxalate

Technical Data
Citations

Biological Activity for MS 245 oxalate

MS 245 oxalate is a high affinity 5-HT₆ antagonist (K_i = 2.1 nM). Potentiates the hypolocomotor actions of (-)-nicotine in mice.

Technical Data for MS 245 oxalate

M. Wt	448.49
Formula	C₁₉H₂₂N₂O₃S.C₂H₂O₄
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	275363-58-1
PubChem ID	6918541
InChi Key	BLSWAEGCRSFTJG-UHFFFAOYSA-N
Smiles	O=S(N2C1=CC=C(OC)C=C1C(CCN(C)C)=C2)(C3=CC=CC=C3)=O.OC(C(O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for MS 245 oxalate

References are publications that support the biological activity of the product.

Young Effect of the 5-HT₆ serotonin antagonist MS-245 on the actions of (-)nicotine. Pharmacol.Biochem.Behav. 2006 PMID: 16950502
Dukat Binding of serotonin and N₁-benzenesulfonyltryptamine-related analogs at human 5-HT₆ serotonin receptors: receptor modeling studies. J.Med.Chem. 2008 PMID: 18201064
Nirogi Novel and potent 5-piperazinyl methyl-N₁-aryl sulfonyl indole derivatives as 5-HT₆ receptor ligands. ACS Med.Chem.Lett.
Glennon 2-substituted tryptamines: agents with selectivity for 5-HT₆ serotonin receptors. J.Med.Chem. 2000 PMID: 10715164

MS 245 oxalate

Tocris Bioscience, part of Bio-Techne | Catalog # 4208

Key Product Details

Biological Activity for MS 245 oxalate

Technical Data for MS 245 oxalate

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for MS 245 oxalate

Product Documents for MS 245 oxalate

COA

Certificate of Analysis

SDS

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