MS 21570
Tocris Bioscience, part of Bio-Techne | Catalog # 6298
GPR171 antagonist
Product Description
MS 21570 is a GPR171 antagonist (IC50 = 220 nM). Inhibits BigLEN (Cat.No. 6304) mediated increases in [35S]GTPγS binding in hypothalamic membranes and hyperpolarization of basolateral amygdala pyramidal neurons. Reduces anxiety-like behavior and fear conditioning in mice.Product Specifications
Molecular Weight
237.34
Formula
C10H11N3S2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-Methyl-5-[(phenylmethyl)thio]-1,3,4-thiazadiazol-2-amine
CAS Number
65373-29-7
PubChem ID
805117
InChI Key
KFLNRVSOQJTXDG-UHFFFAOYSA-N
SMILES
CNC1=NN=C(S1)SCC2=CC=CC=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.73 | 100 | |
| Ethanol | 23.73 | 100 |
Preparing Stock Solutions
for MS 21570
The following data is based on the product molecular weight 237.34
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.21 mL | 21.07 mL | 42.13 mL |
| 5 mM | 0.84 mL | 4.21 mL | 8.43 mL |
| 10 mM | 0.42 mL | 2.11 mL | 4.21 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.84 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Bobeck The BigLEN-GPR171 peptide receptor system within the basolateral amygdala regulates anxiety-like behavior and contextual fear conditioning. Neuropsychopharmacology 2017 PMID: 28425495
Product Specific Notices for MS 21570
For research use only
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