MS 21570

Name: MS 21570
Brand: Tocris Bioscience
SKU: 6298

Tocris Bioscience, part of Bio-Techne | Catalog # 6298

Citations (2)

COA / SDS

GPR171 antagonist

Key Product Details

Description:	GPR171 antagonist
Chemical Name:	N-Methyl-5-[(phenylmethyl)thio]-1,3,4-thiazadiazol-2-amine
Purity:	≥98% (HPLC)
Molecular Weight:	237.34

View Full Technical Details for MS 21570

Technical Data
Citations

Biological Activity for MS 21570

MS 21570 is a GPR171 antagonist (IC₅₀ = 220 nM). Inhibits BigLEN (Cat.No. 6304) mediated increases in [³⁵S]GTPγS binding in hypothalamic membranes and hyperpolarization of basolateral amygdala pyramidal neurons. Reduces anxiety-like behavior and fear conditioning in mice.

Compound Libraries for MS 21570

MS 21570 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for MS 21570

M. Wt	237.34
Formula	C₁₀H₁₁N₃S₂
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	65373-29-7
PubChem ID	805117
InChi Key	KFLNRVSOQJTXDG-UHFFFAOYSA-N
Smiles	CNC1=NN=C(S1)SCC2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MS 21570

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	23.73	100
	ethanol	23.73	100

Preparing Stock Solutions for MS 21570

The following data is based on the product molecular weight 237.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.21 mL	21.07 mL	42.13 mL
5 mM	0.84 mL	4.21 mL	8.43 mL
10 mM	0.42 mL	2.11 mL	4.21 mL
50 mM	0.08 mL	0.42 mL	0.84 mL

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References for MS 21570

References are publications that support the biological activity of the product.

Bobeck The BigLEN-GPR171 peptide receptor system within the basolateral amygdala regulates anxiety-like behavior and contextual fear conditioning. Neuropsychopharmacology 2017 PMID: 28425495