MS 159

Name: MS 159
Brand: Tocris Bioscience
SKU: 8079

Tocris Bioscience, part of Bio-Techne | Catalog # 8079

COA / SDS

NSD2 Degrader (PROTAC®)

Key Product Details

Description:	NSD2 Degrader (PROTAC^®)
Chemical Name:	N-Cyclopropyl-N-(4-((5-(3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)propoxy)pyridin-2-yl)-carbamoyl)benzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide
Purity:	≥98% (HPLC)
Molecular Weight:	828.84

View Full Technical Details for MS 159

Technical Data
Citations

Biological Activity for MS 159

MS 159 is a nuclear receptor binding SET structural domain protein 2 (NSD2) Degrader (DC₅₀ = 5.2 μM, D_max = >82%). Also degrades IKZF3 and IKZF1. Comprises an NSD2 binding moiety joined by a linker to a cereblon E3 ligase ligand. Inhibits proliferation of KMS11 and H929 tumor cells. Bioavailable in vivo.

PROTAC^® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Technical Data for MS 159

M. Wt	828.84
Formula	C₄₃H₄₀N₈O₁₀
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	3031353-59-7
PubChem ID	164887575
InChi Key	OBZWKPGPTCBYOS-UHFFFAOYSA-N
Smiles	O=C(NC1=NC=C(OCCCNC(CNC2=CC=CC3=C2C(N(C4CCC(NC4=O)=O)C3=O)=O)=O)C=C1)C(C=C5)=CC=C5CN(C(C6=CC7=C(NC(CO7)=O)C=C6)=O)C8CC8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MS 159

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	41.44	50

Preparing Stock Solutions for MS 159

The following data is based on the product molecular weight 828.84.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	2.41 mL	12.07 mL	24.13 mL
2.5 mM	0.48 mL	2.41 mL	4.83 mL
5 mM	0.24 mL	1.21 mL	2.41 mL
25 mM	0.05 mL	0.24 mL	0.48 mL

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References for MS 159

References are publications that support the biological activity of the product.

Meng Discovery of a first-in-class degrader for nuclear receptor binding SET domain protein 2 (NSD2) and Ikaros/Aiolos. J.Med.Chem. 2022 PMID: 35895319