MS 159
Tocris Bioscience, part of Bio-Techne | Catalog # 8079
NSD2 Degrader (PROTAC®)
Product Description
MS 159 is a nuclear receptor binding SET structural domain protein 2 (NSD2) Degrader (DC50 = 5.2 μM, Dmax = >82%). Also degrades IKZF3 and IKZF1. Comprises an NSD2 binding moiety joined by a linker to a cereblon E3 ligase ligand. Inhibits proliferation of KMS11 and H929 tumor cells. Bioavailable in vivo.PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Product Specifications
Molecular Weight
828.84
Formula
C43H40N8O10
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
N-Cyclopropyl-N-(4-((5-(3-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)propoxy)pyridin-2-yl)-carbamoyl)benzyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide
CAS Number
3031353-59-7
PubChem ID
164887575
InChI Key
OBZWKPGPTCBYOS-UHFFFAOYSA-N
SMILES
O=C(NC1=NC=C(OCCCNC(CNC2=CC=CC3=C2C(N(C4CCC(NC4=O)=O)C3=O)=O)=O)C=C1)C(C=C5)=CC=C5CN(C(C6=CC7=C(NC(CO7)=O)C=C6)=O)C8CC8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.44 | 50 |
Preparing Stock Solutions
for MS 159
The following data is based on the product molecular weight 828.84
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 2.41 mL | 12.07 mL | 24.13 mL |
| 2.5 mM | 0.48 mL | 2.41 mL | 4.83 mL |
| 5 mM | 0.24 mL | 1.21 mL | 2.41 mL |
| 25 mM | 0.05 mL | 0.24 mL | 0.48 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Meng Discovery of a first-in-class degrader for nuclear receptor binding SET domain protein 2 (NSD2) and Ikaros/Aiolos. J.Med.Chem. 2022 PMID: 35895319
Product Specific Notices for MS 159
For research use only
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