MS 15203
Tocris Bioscience, part of Bio-Techne | Catalog # 6299
Potent and selective GPR171 partial agonist
Discontinued Product
6299 has been discontinued.
View all GPR171 Agonists products.
Key Product Details
Description
Potent and selective GPR171 partial agonist
Product Description
MS 15203 is a potent and selective GPR171 partial agonist (EC50 = 90 nM; 28% inhibition of Forskolin activated adenylyl cyclase activity in rat hypothalamic membranes). Exhibits minimal binding to a panel of ~70 GPCRs and 10 other receptors (<22% of radioligand displaced from the target receptors). Increases neuronal activity in the paraventricular nucleus. Increases food intake and body weight in mice.Product Specifications
Molecular Weight
249.22
Formula
C12H11NO5
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5-[(2-Methyl-1-oxo-2-propen-1-yl)amino]-1,3-benzenedicarboxylic acid
CAS Number
73912-52-4
PubChem ID
773544
InChI Key
NVOBVSWSDYFEMR-UHFFFAOYSA-N
SMILES
CC(C(NC1=CC(C(O)=O)=CC(C(O)=O)=C1)=O)=C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 24.92 | 100 |
Preparing Stock Solutions
for MS 15203
The following data is based on the product molecular weight 249.22
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.01 mL | 20.06 mL | 40.13 mL |
| 5 mM | 0.80 mL | 4.01 mL | 8.03 mL |
| 10 mM | 0.40 mL | 2.01 mL | 4.01 mL |
| 50 mM | 0.08 mL | 0.40 mL | 0.80 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Wardman Identification of a small-molecule ligand that activates the neuropeptide receptor GPR171 and increases food intake Sci.Signal. 2016 PMID: 27245612
Product Specific Notices for MS 15203
For research use only
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