MRT 68921 dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 5780
ULK inhibitor
Product Description
MRT 68921 dihydrochloride is a potent ULK inhibitor (IC50 values are 1.1 and 2.9 nM for ULK2 and ULK1, respectively). Inhibits autophagy in mouse embryonic fibroblasts.Product Specifications
Molecular Weight
507.50
Formula
C25H34N6O.2HCl
Storage
Desiccate at RT
Purity
≥98% (HPLC)
Chemical Name
N-[3-[[5-Cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide dihydrochloride
CAS Number
2080306-21-2
PubChem ID
124201611
InChI Key
NLKPLTWKINJHCK-UHFFFAOYSA-N
SMILES
CN1CCC2=CC(NC3=NC=C(C(NCCCNC(C4CCC4)=O)=N3)C5CC5)=CC=C2C1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 50.75 | 100 |
Preparing Stock Solutions
for MRT 68921 dihydrochloride
The following data is based on the product molecular weight 507.50
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.97 mL | 9.85 mL | 19.70 mL |
| 5 mM | 0.39 mL | 1.97 mL | 3.94 mL |
| 10 mM | 0.20 mL | 0.99 mL | 1.97 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.39 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Petherick Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy. J.Biol.Chem. 2015 PMID: 25833948
Product Specific Notices for MRT 68921 dihydrochloride
For research use only
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