MRS 2279

Name: MRS 2279
Brand: Tocris Bioscience
SKU: 2158
Price: 469 USD

Tocris Bioscience a Bio-Techne Brand

Catalog # 2158

Citations (5)

COA / SDS

Catalog #

Availability

Size / Price

Qty

Key Product Details

Description:	Selective, high affinity P2Y₁ antagonist
Chemical Name:	(1R,2S)-4-[2-Chloro-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hexane-1-methanol dihydrogen phosphate ester diammonium salt
Purity:	≥98% (HPLC)
Molecular Weight:	503.78

View Full Technical Details for MRS 2279

Biological Activity for MRS 2279

MRS 2279 is a selective, high affinity competitive antagonist of the P2Y₁ receptor (K_i = 2.5 nM; IC₅₀ = 51.6 nM). Fails to block nucleotide signaling at most other P2Y receptors (P2Y₂, P2Y₄, P2Y₆, P2Y₁₁ and P2Y₁₂) and potently inhibits ADP-induced aggregation of human blood platelets in vitro (pK_B = 8.05).

Licensing Information

Sold under license from the NIH, US Patent 10/169975

Technical Data for MRS 2279

M. Wt	503.78
Formula	C₁₃H₁₈ClN₅O₈P₂.2NH₃
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	2387505-47-5
PubChem ID	90488744
InChi Key	MLPKPDFUVMQAOX-KOVKCLEESA-N
Smiles	ClC4=NC1=C(C(NC)=N4)N=CN1[C@H]2C[C@H](OP(O)(O)=O)[C@@]3(COP(O)(O)=O)[C@@H]2C3.N.N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MRS 2279

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	50.38	100

Preparing Stock Solutions for MRS 2279

The following data is based on the product molecular weight 503.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.98 mL	9.92 mL	19.85 mL
5 mM	0.40 mL	1.98 mL	3.97 mL
10 mM	0.20 mL	0.99 mL	1.98 mL
50 mM	0.04 mL	0.20 mL	0.40 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for MRS 2279

References are publications that support the biological activity of the product.

Kim 2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y₁ receptor antagonists. J.Med.Chem 2003 PMID: 14584948
Boyer 2-Chloro N⁶-methyl-(N)-methanocarba-2'-deoxyadenosine-3',5'-bisphosphate is a selective high affinity P2Y₁ receptor antagonist. Br.J.Pharmacol. 2002 PMID: 11959804
Nandanan Synthesis, biological activity, and molecular modeling of ribose-modified deoxyadenosine bisphosphate analogues as P2Y₁ receptor ligands. J.Med.Chem. 2000 PMID: 10715151

Citations for MRS 2279 (5)

Showing 1 - 5 of 5 citations Showing All

Search Title:

Citations are publications that use Bio-Techne products. Selected citations for MRS 2279 include:

Dosch et al. (2019) Connexin-43-dependent ATP release mediates macrophage activation during sepsis. Elife. 8
PMID: 30735126
Wilkaniec et al. (2017) P2X7 receptor-pannexin 1 interaction mediates extracellular alpha-synuclein-induced ATP release in neuroblastoma SH-SY5Y cells. Purinergic Signal. 13:347
PMID: 28516276
Ohtomo et al. (2011) Increase of intracellular Ca²⁺ by purinergic receptors in cultured rat lacrimal gland myoepithelial cells. Invest Ophthalmol Vis Sci. 52:9503
PMID: 22039237
Kuboyama et al. (2011) Astrocytic P2Y(1) receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral ischemia. Cell Death Dis. 31:1930
PMID: 21487414
Harper and Poole (2010) Protein kinase Ctheta negatively regulates store-independent Ca²⁺ entry and phosphatidylserine exposure downstream of glycoprotein VI in platelets. J Biol Chem. 285:19865
PMID: 20388711

There are no citations that match your criteria.

Showing 1 - 5 of 5 citations Showing All

Product Documents for MRS 2279

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.