MRS 1754

Name: MRS 1754
Brand: Tocris Bioscience
SKU: 2752

Tocris Bioscience, part of Bio-Techne | Catalog # 2752

Citations (81)

COA / SDS

Selective A2B antagonist

Key Product Details

Description:	Selective A_2B antagonist
Chemical Name:	N-(4-Cyanophenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	486.52

View Full Technical Details for MRS 1754

Technical Data
Citations

Biological Activity for MRS 1754

MRS 1754 is a selective adenosine A_2B receptor antagonist (K_i values are 1.97, 16.8, 403, 503, 570 and 612 nM for hA_2B, rA₁, hA₁, hA_2A, hA₃ and rA_2A receptors respectively).

Licensing Information

Sold with the permission of the University of Virginia Patent Foundation

Technical Data for MRS 1754

M. Wt	486.52
Formula	C₂₆H₂₆N₆O₄
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	264622-58-4
PubChem ID	6603931
InChi Key	AJBBEYXFRYFVNM-UHFFFAOYSA-N
Smiles	CCCN1C2=C(NC(=N2)C2=CC=C(OCC(=O)NC3=CC=C(C=C3)C#N)C=C2)C(=O)N(CCC)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MRS 1754

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	2.43	5 with gentle warming

Preparing Stock Solutions for MRS 1754

The following data is based on the product molecular weight 486.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.05 mM	41.11 mL	205.54 mL	411.08 mL
0.25 mM	8.22 mL	41.11 mL	82.22 mL
0.5 mM	4.11 mL	20.55 mL	41.11 mL
2.5 mM	0.82 mL	4.11 mL	8.22 mL

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References for MRS 1754

References are publications that support the biological activity of the product.

Ji [³H]MRS 1754, a selective antagonist radioligand for A_2B adenosine receptors. Biochem.Pharmacol. 2001 PMID: 11266650
Nemeth Adenosine receptor activation ameliorates type I diabetes. FASEB J.
Kim Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A_2B adenosine receptors. J.Med.Chem. 2000 PMID: 10737749