MRS 1754

Name: MRS 1754
Brand: Tocris Bioscience
SKU: 2752

Catalog # 2752 | Tocris Bioscience a Bio-Techne Brand

Citations (16)

COA / SDS

Selective A2B antagonist

Key Product Details

Description:	Selective A_2B antagonist
Chemical Name:	N-(4-Cyanophenyl)-2-[4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy]-acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	486.52

View Full Technical Details for MRS 1754

Technical Data
Citations (16) / Reviews

Biological Activity for MRS 1754

MRS 1754 is a selective adenosine A_2B receptor antagonist (K_i values are 1.97, 16.8, 403, 503, 570 and 612 nM for hA_2B, rA₁, hA₁, hA_2A, hA₃ and rA_2A receptors respectively).

Licensing Information

Sold with the permission of the University of Virginia Patent Foundation

Technical Data for MRS 1754

M. Wt	486.52
Formula	C₂₆H₂₆N₆O₄
Storage	Desiccate at RT
Purity	≥98% (HPLC)
CAS Number	264622-58-4
PubChem ID	6603931
InChi Key	AJBBEYXFRYFVNM-UHFFFAOYSA-N
Smiles	CCCN1C2=C(NC(=N2)C2=CC=C(OCC(=O)NC3=CC=C(C=C3)C#N)C=C2)C(=O)N(CCC)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MRS 1754

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	2.43	5 with gentle warming
	DMSO	4.87	10 with sonication

Preparing Stock Solutions for MRS 1754

The following data is based on the product molecular weight 486.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.55 mL	102.77 mL	205.54 mL
0.5 mM	4.11 mL	20.55 mL	41.11 mL
1 mM	2.06 mL	10.28 mL	20.55 mL
5 mM	0.41 mL	2.06 mL	4.11 mL

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References for MRS 1754

References are publications that support the biological activity of the product.

Nemeth Adenosine receptor activation ameliorates type I diabetes. FASEB J.
Ji [³H]MRS 1754, a selective antagonist radioligand for A_2B adenosine receptors. Biochem.Pharmacol. 2001 PMID: 11266650
Kim Anilide derivatives of an 8-phenylxanthine carboxylic congener are highly potent and selective antagonists at human A_2B adenosine receptors. J.Med.Chem. 2000 PMID: 10737749

Citations for MRS 1754 (16)

Showing 1 - 10 of 16 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for MRS 1754 include:

Liu et al. (2018) Adenosine binds predominantly to adenosine receptor A₁ subtype in astrocytes and mediates an immunosuppressive effect. Brain Res. 1700:47
PMID: 29935155
Asano (2017) Aminophylline suppresses stress-induced visceral hypersensitivity and defecation in irritable bowel syndrome. Scientific Reports. 7:40214
PMID: 28054654
Wakisaka et al. (2017) An Adenosine Receptor for Olfaction in Fish. Curr Biol. 27:1437
PMID: 28502661
Ledderose et al. (2016) Adenosine arrests breast cancer cell motility by A3 receptor stimulation. Purinergic Signalling. 2016;
PMID: 27577957
Kohno et al. (2015) Anti-inflammatory effects of adenosine N1-oxide. Am J Physiol Lung Cell Mol Physiol. 12:2
PMID: 25632271
Lemos et al. (2015) Adenosine A2B receptor activation stimulates glucose uptake in the mouse forebrain. Purinergic Signal. 11:561
PMID: 26446689
Welihinda and Amento (2014) Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation. J Inflamm (Lond). 11:37
PMID: 25473378
He et al. (2013) Adenosine regulates bone metabolism via A1, A2A, and A2B receptors in bone marrow cells from normal humans and patients with multiple myeloma. FASEB J. 27:3446
PMID: 23682121
Garção et al. (2013) Functional interaction between pre-synaptic α6β2-containing nicotinic and adenosine A2A receptors in the control of DA release in the rat striatum. Br J Pharmacol. 169:1600
PMID: 23638679
Kan et al. (2012) Imiquimod suppresses propagation of herpes simplex virus 1 by upregulation of cystatin A via the adenosine receptor A1 pathway. J Virol. 86:10338
PMID: 22787201
Hua et al. (2011) IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors. PLoS One. 6:e24947
PMID: 21966389
Pedroza et al. (2011) Interleukin-6 contributes to inflammation and remodeling in a model of adenosine mediated lung injury. Mol Vis. 6:e22667
PMID: 21799929
Zhan et al. (2011) Adenosine A2A and A2B receptors are both required for adenosine A1 receptor-mediated cardioprotection. Am J Physiol Heart Circ Physiol. 301:H1183
PMID: 21743001
Gebremedhin et al. (2010) Adenosine can mediate its actions through generation of reactive oxygen species. J Cereb Blood Flow Metab. 30:1777
PMID: 20531463
Yu et al. (2009) Effect of ventilation pressure on alveolar fluid clearance and β-agonist responses in mice. Am J Respir Crit Care Med. 297:L785
PMID: 19684202
Wolk et al. (2008) Influenza A virus inhibits alveolar fluid clearance in BALB/c mice. PLoS One. 178:969
PMID: 18689466

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