MR 24
Tocris Bioscience, part of Bio-Techne | Catalog # 8122
Potent and selective MST3 kinase binding inhibitor
Key Product Details
Description
Potent and selective MST3 kinase binding inhibitor
Product Description
MR 24 is a potent and selective MST3 kinase binding inhibitor with >10 fold selectivity over MST4 (EC50 values from NanoBRET assay are 57 nM and 583 nM for MST3 and MST4 respectively). MR 24 increases the number of cells in G1 phase of cell cycle, is non-cytotoxic and cell permeable. Shows 90% stability over 1 hour in activated liver microsomes in vivo.Product Specifications
Molecular Weight
618.38
Formula
C26H29ClN6O3.3HCl
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
8-(4-Aminobutyl)-6-[2-chloro-4-(6-methylpyridin-2-yl)phenyl]-2-(1,3-dihydroxypropan-2-ylamino)pyrido[2,3-d]pyrimidin-7-one trihydrochloride
InChI Key
GDJVKNSFYAPEKT-UHFFFAOYSA-N
SMILES
CC1=CC=CC(C2=CC(Cl)=C(C3=CC(C=NC(NC(CO)CO)=N4)=C4N(CCCCN)C3=O)C=C2)=N1.Cl.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.92 | 50 |
Preparing Stock Solutions
for MR 24
The following data is based on the product molecular weight 618.38
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 3.23 mL | 16.17 mL | 32.34 mL |
| 2.5 mM | 0.65 mL | 3.23 mL | 6.47 mL |
| 5 mM | 0.32 mL | 1.62 mL | 3.23 mL |
| 25 mM | 0.06 mL | 0.32 mL | 0.65 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Rak Development of selective pyrido[2,3.d]pyrimidin-7(8H).one-based mammalian STE20-Like (MST3/4) kinase inhibitors. J.Med.Chem.
Product Specific Notices for MR 24
For research use only
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