MPP dihydrochloride
Tocris Bioscience, part of Bio-Techne | Catalog # 1991
Highly selective ERα antagonist
Key Product Details
Description
Highly selective ERα antagonist
Product Description
MPP dihydrochloride is a selective, high affinity silent antagonist at ERα receptors. Displays > 200-fold selectivity for ERα over ERβ. Ki values are 2.7 and 1800 nM at ERα and ERβ receptors respectively.Product Specifications
Molecular Weight
542.50
Formula
C29H31N3O3.2HCl
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
1,3-Bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride
CAS Number
911295-24-4
PubChem ID
45073474
InChI Key
SMPRQALBFACGGO-UHFFFAOYSA-N
SMILES
OC(C=C4)=CC=C4N1C(C(C=C3)=CC=C3OCCN2CCCCC2)=C(C)C(C5=CC=C(O)C=C5)=N1.Cl.Cl
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 54.25 | 100 |
Preparing Stock Solutions
for MPP dihydrochloride
The following data is based on the product molecular weight 542.50
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.84 mL | 9.22 mL | 18.43 mL |
| 5 mM | 0.37 mL | 1.84 mL | 3.69 mL |
| 10 mM | 0.18 mL | 0.92 mL | 1.84 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.37 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Sun Antagonists selective for estrogen receptor α. Endocrinol. 2002 PMID: 11861516
- Harrington Activities of estrogen receptor alpha- and beta-selective ligands at diverse responsive gene sites mediating transactivation or transrepression. Mol.Cell.Endocrinol. 2003 PMID: 12943986
Product Specific Notices for MPP dihydrochloride
For research use only
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