MONNA

Tocris Bioscience, part of Bio-Techne | Catalog # 5770

Potent TMEM16A (Anoctamin-1) blocker
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Key Product Details

Description

Potent TMEM16A (Anoctamin-1) blocker

View all Calcium-activated Chloride Channel Blockers »

Product Description

MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC50 = 80 nM). Exhibits >100-fold selectivity for TMEM16A over bestrophin-1, CLC2 and CFTR. Induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions. Carbachol (Cat. No. 2810) induced contraction of bronchial myocytes is reduced by MONNA and intracellular calcium release is increased.

Product Specifications

Molecular Weight

338.31

Formula

C18H14N2O5

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid

CAS Number

1572936-83-4

PubChem ID

72165188

InChI Key

JIVRLHBAUUZTNC-UHFFFAOYSA-N

SMILES

COC1=CC(NC2=C(C(O)=O)C=C([N+]([O-])=O)C=C2)=CC3=C1C=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.83 100

Preparing Stock Solutions for MONNA

The following data is based on the product molecular weight 338.31

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.96 mL 14.78 mL 29.56 mL
5 mM 0.59 mL 2.96 mL 5.91 mL
10 mM 0.30 mL 1.48 mL 2.96 mL
50 mM 0.06 mL 0.30 mL 0.59 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for MONNA

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for MONNA

For research use only

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