MONNA

Name: MONNA
Brand: Tocris Bioscience
SKU: 5770

Tocris Bioscience, part of Bio-Techne | Catalog # 5770

Citations (12)

COA / SDS

Potent TMEM16A (Anoctamin-1) blocker

Key Product Details

Description:	Potent TMEM16A (Anoctamin-1) blocker
Chemical Name:	2-[(4-Methoxy-2-naphthalenyl)amino]-5-nitro-benzoic acid
Purity:	≥98% (HPLC)
Molecular Weight:	338.31

View Full Technical Details for MONNA

Technical Data
Citations

Biological Activity for MONNA

MONNA is a potent TMEM16A (Anoctamin-1) blocker (IC₅₀ = 80 nM). Exhibits >100-fold selectivity for TMEM16A over bestrophin-1, CLC2 and CFTR. Induces vasorelaxation of rodent resistance arteries in presence or absence of chloride ions. Carbachol (Cat. No. 2810) induced contraction of bronchial myocytes is reduced by MONNA and intracellular calcium release is increased.

Technical Data for MONNA

M. Wt	338.31
Formula	C₁₈H₁₄N₂O₅
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1572936-83-4
PubChem ID	72165188
InChi Key	JIVRLHBAUUZTNC-UHFFFAOYSA-N
Smiles	COC1=CC(NC2=C(C(O)=O)C=C([N+]([O-])=O)C=C2)=CC3=C1C=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MONNA

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	33.83	100

Preparing Stock Solutions for MONNA

The following data is based on the product molecular weight 338.31.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.96 mL	14.78 mL	29.56 mL
5 mM	0.59 mL	2.96 mL	5.91 mL
10 mM	0.30 mL	1.48 mL	2.96 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

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Reconstitution Calculator

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References for MONNA

References are publications that support the biological activity of the product.

Boedtkjer New selective inhibitors of calcium-activated chloride channels - T16A(inh) -A01, CaCC(inh) -A01 and MONNA - what do they inhibit? Br.J.Pharmacol. 2015 PMID: 26013995
Dwivedi The TMEM16A blockers benzbromarone and MONNA cause intracellular Ca²⁺-release in mouse bronchial smooth muscle cells. Eur.J.Pharmacol. 2023 PMID: 36967079
Oh MONNA, a potent and selective blocker for transmembrane protein with unknown function 16/anoctamin-1. Mol.Pharmacol. 2013 PMID: 23997117