MOG (35-55)

Name: MOG (35-55)
Brand: Tocris Bioscience
SKU: 2568

Tocris Bioscience, part of Bio-Techne | Catalog # 2568

Citations (12)

COA / SDS

Encephalitogenic myelin oligodendrocyte glycoprotein fragment

Key Product Details

Description:	Encephalitogenic myelin oligodendrocyte glycoprotein fragment
Purity:	≥95% (HPLC)
Molecular Weight:	2581.97

View Full Technical Details for MOG (35-55)

Technical Data
Citations

Biological Activity for MOG (35-55)

MOG (35-55) or myelin oligodendrocyte glycoprotein (MOG) 35-55 is a minor component of CNS myelin. MOG (35-55) produces a relapsing-remitting neurological disease with extensive plaque-like demyelination, common to the manifestations of multiple sclerosis. MOG (35-55) induces strong T and B cell responses and is highly encephalitogenic. MOG (35-55) induces T cell-mediated multiple sclerosis in animal models. When co-administered with ITE, MOG (35-55) induces tolerogenic dendritic cells and suppresses disease development in mouse preclinical models of multiple sclerosis.

Technical Data for MOG (35-55)

M. Wt	2581.97
Formula	C₁₁₈H₁₇₇N₃₅O₂₉S
Single Letter Sequence	MEVGWYRSPFSRVVHLYRNGK
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	149635-73-4
PubChem ID	24868190
InChi Key	JMTCEFUSRHYJBF-DDJPMISGSA-N
Smiles	[H]N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CCCCN)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MOG (35-55)

Solubility

Soluble to 0.5mg/ml in water

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References for MOG (35-55)

References are publications that support the biological activity of the product.

Miyamura Myelin oligodendrocyte glycoprotein 35-55 (MOG 35-55)-induced experimental autoimmune encephalomyelitis: a model of chronic multiple sclerosis. Bio.Protoc. 2019 PMID: 33654948
Kenison Tolerogenic nanoparticles suppress central nervous system inflammation. Proc.Natl.Acad.Sci.U.S.A. 2020 PMID: 33239445
Slavin Induction of a multiple sclerosis-like disease in mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein. Autoimmunity 1998 PMID: 9771980
Zhang T cell and antibody responses in remitting-relapsing experimental autoimmune encephalomyelitis in (C57BL/6xSJL) F1 mice. J.Neuroimmunol. 2004 PMID: 14975581
Ichikawa Analysis of the fine B cell specificity during the chronic/relapsing course of a multiple sclerosis-like disease in Lewis rats injected with the encephalitogenic myelin oligodendrocyte glycoprotein peptide 35-55. J.Immunol. 1996 PMID: 8752946