MNI 137
Tocris Bioscience, part of Bio-Techne | Catalog # 4388
Selective negative allosteric modulator of group II mGlu receptors
Key Product Details
Description
Selective negative allosteric modulator of group II mGlu receptors
Product Description
MNI 137 is a selective negative allosteric modulator of group II mGlu receptors (IC50 values are 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization). Displays no activity at mGlu1, mGlu4, mGlu5 or mGlu8 receptors in a calcium mobilization assay.Product Specifications
Molecular Weight
341.16
Formula
C15H9BrN4O
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
4-(8-Bromo-2,3-dihydro-2-oxo-1H-1,5-benzodiazepin-4-yl)-2-pyridinecarbonitrile
CAS Number
946619-21-2
PubChem ID
25210562
InChI Key
KMKZCMKOSAKVGY-UHFFFAOYSA-N
SMILES
O=C1CC(C3=CC=NC(C#N)=C3)=NC2=C(C=C(Br)C=C2)N1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 17.06 | 50 |
Preparing Stock Solutions
for MNI 137
The following data is based on the product molecular weight 341.16
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.86 mL | 29.31 mL | 58.62 mL |
| 2.5 mM | 1.17 mL | 5.86 mL | 11.72 mL |
| 5 mM | 0.59 mL | 2.93 mL | 5.86 mL |
| 25 mM | 0.12 mL | 0.59 mL | 1.17 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hemstapat A novel family of potent negative allosteric modulators of group II metabotropic glutamate receptors. J.Pharmacol.Exp.Ther. 2007 PMID: 17416742
Product Specific Notices for MNI 137
For research use only
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