MMG 11

Name: MMG 11
Brand: Tocris Bioscience
SKU: 6858

Tocris Bioscience, part of Bio-Techne | Catalog # 6858

Citations (5)

COA / SDS

TLR2 antagonist

Key Product Details

Description:	TLR2 antagonist
Chemical Name:	Ethyl 5-(2-oxo-2-(2,3,4-trihydroxyphenyl)ethyl)furan-2-carboxylate
Purity:	≥97% (HPLC)
Molecular Weight:	306.27

View Full Technical Details for MMG 11

Technical Data
Citations

Biological Activity for MMG 11

MMG 11 is a TLR2 antagonist (IC₅₀ values are in the range 1.7 - 5.7 μM). Exhibits selectivity for TLR2 over TLR4, TLR5, TLR7/8 and TLR9. Reduces TLR2-mediated cytokine secretion from PBMCs. MMG 11 preferentially inhibits TLR2/1- over TLR2/6-mediated NK-κB activation (IC₅₀ values are 0.87 and 7.4 μM, respectively).

Technical Data for MMG 11

M. Wt	306.27
Formula	C₁₅H₁₄O₇
Storage	Store at -20°C
Purity	≥97% (HPLC)
CAS Number	313254-94-3
PubChem ID	854609
InChi Key	IIDUJWIVMGALOG-UHFFFAOYSA-N
Smiles	CCOC(=O)C1=CC=C(CC(=O)C2=C(O)C(O)=C(O)C=C2)O1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for MMG 11

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	30.63	100
	ethanol	15.31	50

Preparing Stock Solutions for MMG 11

The following data is based on the product molecular weight 306.27.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.27 mL	16.33 mL	32.65 mL
5 mM	0.65 mL	3.27 mL	6.53 mL
10 mM	0.33 mL	1.63 mL	3.27 mL
50 mM	0.07 mL	0.33 mL	0.65 mL

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References for MMG 11

References are publications that support the biological activity of the product.

Grabowski The novel small-molecule antagonist MMG-11 preferentially inhibits TLR2/1 signaling. Biochem.Pharmacol. 2020 PMID: 31678495
Grabowski Identification of a pyrogallol derivative as a potent and selective human TLR2 antagonist by structure-based virtual screening. Biochem.Pharmacol. 2019 PMID: 29684378