MLR 1023
Tocris Bioscience, part of Bio-Techne | Catalog # 4582
Selective allosteric activator of Lyn kinase
Key Product Details
Description
Selective allosteric activator of Lyn kinase
Product Description
MLR 1023 is a selective allosteric activator of Lyn kinase (EC50 = 63 nM); displays no significant activity against a range of 47 other kinases, including other Src family kinases such as Fyn, Lck and Src kinase. Reduces blood glucose levels without affecting in vivo insulin secretion. Orally bioavailable.Product Specifications
Molecular Weight
202.21
Formula
C11H10N2O2
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
5-(3-Methylphenoxy)-2(1H)-pyrimidinone
CAS Number
41964-07-2
PubChem ID
39065
InChI Key
HJQILFPVRNHTIG-UHFFFAOYSA-N
SMILES
CC1=CC(OC2=CNC(N=C2)=O)=CC=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.22 | 100 | |
| Ethanol | 4.04 | 20 |
Preparing Stock Solutions
for MLR 1023
The following data is based on the product molecular weight 202.21
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.95 mL | 24.73 mL | 49.45 mL |
| 5 mM | 0.99 mL | 4.95 mL | 9.89 mL |
| 10 mM | 0.49 mL | 2.47 mL | 4.95 mL |
| 50 mM | 0.10 mL | 0.49 mL | 0.99 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Saporito MLR-1023 is a potent and selective allosteric activator of Lyn kinase in vitro that improves glucose tolerance in vivo. J.Pharmacol.Exp.Ther. 2012 PMID: 22473614
- Ochman The Lyn kinase activator MLR-1023 is a novel Ins receptor potentiator that elicits a rapid-onset and durable improvement in glucose homeostasis in animal models of type 2 diabetes. J.Pharmacol.Exp.Ther. 2012 PMID: 22431203
Product Specific Notices for MLR 1023
For research use only
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