MLi-2
Tocris Bioscience, part of Bio-Techne | Catalog # 5756
Potent and selective LRRK2 inhibitor
Product Description
MLi-2 is a potent and selective LRRK2 inhibitor (IC50 = 0.76-3.4 nM depending on assay), which exhibits >295-fold selectivity for over 300 kinases and a diverse panel of receptors and ion channels. MLi-2 is centrally bioavailable and active in vivo.External Portal Information
Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of MLi-2 is reviewed on chemicalprobes.org and the SGC website.Product Specifications
Molecular Weight
379.46
Formula
C21H25N5O2
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
rel-3-[6-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-pyrimidyl]-5-[(1-methylcyclopropyl)oxy]-1H-indazole
CAS Number
1627091-47-7
PubChem ID
78319901
InChI Key
ATUUNJCZCOMUKD-OKILXGFUSA-N
SMILES
CC1(CC1)OC2=CC=C3C(C(C4=NC=NC(N5C[C@@H](C)O[C@@H](C)C5)=C4)=NN3)=C2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.97 | 50 |
Preparing Stock Solutions
for MLi-2
The following data is based on the product molecular weight 379.46
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 5.27 mL | 26.35 mL | 52.71 mL |
| 2.5 mM | 1.05 mL | 5.27 mL | 10.54 mL |
| 5 mM | 0.53 mL | 2.64 mL | 5.27 mL |
| 25 mM | 0.11 mL | 0.53 mL | 1.05 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Fell MLi-2, a potent, selective, and centrally active compound for exploring the therapeutic potential and safety of LRRK2 kinase inhibition. J.Pharmacol.Exp.Ther. 2015 PMID: 26407721
Product Specific Notices for MLi-2
For research use only
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