ML T7
Tocris Bioscience, part of Bio-Techne | Catalog # 8119
Inhibitor of phosphatidylserine/CEACAM1 binding to Tim-3
Key Product Details
Description
Inhibitor of phosphatidylserine/CEACAM1 binding to Tim-3
Product Description
ML T7 is a T cell immunoglobulin and mucin-containing molecule 3 (Tim-3) inhibitor; disrupts phosphatidylserine/CAECAM1 binding to Tim-3 (Kd = 7.0 μM and 7.4 μM for hTim-3 and mTim-3 respectively). ML T7 promotes cell proliferation, cytokine production and cytotoxicity of OT-I CD8+ cytotoxic T lymphocytes. ML T7 inhibits tumor growth in a syngeneic mouse model of hepatocellular carcinoma, increases NK cell tumor killing activity and DC maturation.Product Specifications
Molecular Weight
506.34
Formula
C27H17Cl2NO5
Storage
Store at -20°C
Purity
≥98% (HPLC)
Chemical Name
5-(2,4-Dichlorophenyl)-3a,6a-dihydro-3-(4-methylphenyl)spiro[1H-furo[3,4-c]pyrrole-1,2'-[2H]indene]-1',3',4,6(3H,5H)-tetrone
CAS Number
459789-75-4
PubChem ID
3116616
InChI Key
OFJOQMMYCMPPEC-UHFFFAOYSA-N
SMILES
ClC1=CC=C(C(Cl)=C1)N2C(C(C3C2=O)C(OC43C(C5=C(C4=O)C=CC=C5)=O)C6=CC=C(C=C6)C)=O
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.63 | 100 |
Preparing Stock Solutions
for ML T7
The following data is based on the product molecular weight 506.34
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.97 mL | 9.87 mL | 19.75 mL |
| 5 mM | 0.39 mL | 1.97 mL | 3.95 mL |
| 10 mM | 0.20 mL | 0.99 mL | 1.97 mL |
| 50 mM | 0.04 mL | 0.20 mL | 0.39 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Ma Identification of a small-molecule Tim-3 inhibitor to potentiate T cell-mediated antitumor immunotherapy in preclinical mouse models. Sci.Transl.Med. 2023 PMID: 37967204
Product Specific Notices for ML T7
For research use only
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