ML SA1

Name: ML SA1
Brand: Tocris Bioscience
SKU: 4746

Tocris Bioscience, part of Bio-Techne | Catalog # 4746

Citations (47)

COA / SDS

Activator of TRPML channels

Key Product Details

Description:	Activator of TRPML channels
Chemical Name:	2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
Purity:	≥98% (HPLC)
Molecular Weight:	362.42

View Full Technical Details for ML SA1

Technical Data
Citations

Biological Activity for ML SA1

ML SA1 is an activator of TRPML channels (TRPML1, 2 and 3); does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels. Induces TRPML-mediated Ca²⁺ release from lysosomes; activity corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages. Activation of TRPML1 by ML SA1 causes membrane accumulation of aquaporin-3 and -5, and significant depolymerization of the actin cytoskeleton, in human lymphatic endothelial cells (HLECs).

Compound Libraries for ML SA1

ML SA1 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML SA1

M. Wt	362.42
Formula	C₂₂H₂₂N₂O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	332382-54-4
PubChem ID	2880983
InChi Key	KDDHBJICVBONAX-UHFFFAOYSA-N
Smiles	CC2CC(C)(C)N(C(CN3C(C(C=CC=C4)=C4C3=O)=O)=O)C1=CC=CC=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML SA1

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	7.25	20

Preparing Stock Solutions for ML SA1

The following data is based on the product molecular weight 362.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.80 mL	68.98 mL	137.96 mL
1 mM	2.76 mL	13.80 mL	27.59 mL
2 mM	1.38 mL	6.90 mL	13.80 mL
10 mM	0.28 mL	1.38 mL	2.76 mL

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References for ML SA1

References are publications that support the biological activity of the product.

Weiss Cross-talk between TRPML1 channel, lipids and lysosomal storage diseases. Commun.Integr.Biol. 2012 PMID: 22808310
Yang TRPML1 acts as a predisposing factor in lymphedema development by regulating the subcellular localization of aquaporin-3, -5. PLoS One 2024 PMID: 39637010
Shen Lipid storage disorders block lysosomal trafficking by inhibiting TRP channel and calcium release. Nat.Commun. 2012 PMID: 22415822