ML 9 hydrochloride

Name: ML 9 hydrochloride
Brand: tocris
SKU: 0431

Catalog # 0431

Citations (4)

Datasheet / COA / SDS

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Key Product Details

Description:	Myosin light chain kinase inhibitor
Chemical Name:	1-(5-Chloronaphthalenesulfonyl)homopiperazine hydrochloride
Purity:	≥99% (HPLC)
Molecular Weight:	361.29

View Full Technical Details for ML 9 hydrochloride

Biological Activity

Selective MLCK inhibitor (K_i values are 4, 32 and 54 μM for MLCK, PKA and PKC respectively). Also inhibits STIM1-plasma membrane interactions, preventing store-operated Ca²⁺ entry (SOCE).

Compound Libraries

ML 9 hydrochloride is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Kinase Inhibitor Library. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt	361.29
Formula	C₁₅H₁₇ClN₂O₂S.HCl
Storage	Desiccate at RT
Purity	≥99% (HPLC)
CAS Number	105637-50-1
PubChem ID	108047
InChi Key	ZNRYCIVTNLZOGI-UHFFFAOYSA-N
Smiles	Cl.ClC1=C2C=CC=C(C2=CC=C1)S(=O)(=O)N1CCCNCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.03	25

Preparing Stock Solutions

The following data is based on the product molecular weight 361.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	11.07 mL	55.36 mL	110.71 mL
1.25 mM	2.21 mL	11.07 mL	22.14 mL
2.5 mM	1.11 mL	5.54 mL	11.07 mL
12.5 mM	0.22 mL	1.11 mL	2.21 mL

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References

References are publications that support the biological activity of the product.

Hidaka and Koybashi Pharmacology of protein kinase inhibitors. Annu.Rev.Pharmacol.Toxicol. 1992 PMID: 1605572
Seto Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle. Eur.J.Pharmacol. 1991 PMID: 1874276
Varnai STIM and Orai: the long-awaited constituents of store-operated calcium entry. TiPS 2009 PMID: 19187978
Hidaka and Hagiwara Pharmacology of the isoquinoline sulfonamide protein kinase C inhibitors. Trends Pharmacol.Sci.

Citations (4)

Showing 1 - 4 of 4 citations Showing All

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Citations are publications that use Bio-Techne products. Selected citations for ML 9 hydrochloride include:

Dobson et al. (2015) Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling. J Pharmacol Exp Ther. 10:e0125974
PMID: 25933382
Kirschstein et al. (2014) Age-dependent contribution of Rho kinase in CB-induced contraction of human detrusor smooth muscle in vitro. Acta Pharmacol Sin. 35:74
PMID: 24122009
Siddoway et al. (2013) An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling. PLoS One. 33:11206
PMID: 23825423
Gruszczynska-Biegala et al. (2011) Differential roles for STIM1 and STIM2 in store-operated calcium entry in rat neurons. PLoS One. 6:e19285
PMID: 21541286

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Product Datasheets

COA

Certificate of Analysis

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ML 9 hydrochloride

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References

Citations (4)

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