ML 218 hydrochloride

Name: ML 218 hydrochloride
Brand: Tocris Bioscience
SKU: 4507

Tocris Bioscience, part of Bio-Techne | Catalog # 4507

Citations (13)

COA / SDS

CaV3.x blocker

Key Product Details

Description:	Ca_V3.x blocker
Chemical Name:	3,5-Dichloro-N-[[(1α,5α,6-exo,6α)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hex-6-yl]methyl]-benzamide hydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	405.79

View Full Technical Details for ML 218 hydrochloride

Technical Data
Citations

Biological Activity for ML 218 hydrochloride

ML 218 hydrochloride is a selective inhibitor of T-type calcium channels (IC₅₀ values are 270 and 310 nM for Ca_v3.3 and Ca_v3.2 respectively in a patch EP assay). Decreases burst activity in STN neurons; reduces cataleptic behaviour in an in vivo rat model of Parkinson's disease. Displays no significant inhibition of L- or N-type calcium channels, K_ir6 (K_ATP) or K_V11.1 (hERG) potassium channels. ML 218 hydrochloride inhibits oral cancer cell proliferation. Orally active.

Compound Libraries for ML 218 hydrochloride

ML 218 hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ML 218 hydrochloride

M. Wt	405.79
Formula	C₁₉H₂₆Cl₂N₂O.HCl
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	2319922-08-0
PubChem ID	2723792
InChi Key	JIQFFACVQXXHMY-YDALLXLXSA-N
Smiles	CC(C)(C)CCN1C[C@@]2([H])[C@@]([C@@H]2CNC(C3=CC(Cl)=CC(Cl)=C3)=O)([H])C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 218 hydrochloride

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	36.93	100
	ethanol	36.93	100

Preparing Stock Solutions for ML 218 hydrochloride

The following data is based on the product molecular weight 405.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.46 mL	12.32 mL	24.64 mL
5 mM	0.49 mL	2.46 mL	4.93 mL
10 mM	0.25 mL	1.23 mL	2.46 mL
50 mM	0.05 mL	0.25 mL	0.49 mL

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References for ML 218 hydrochloride

References are publications that support the biological activity of the product.

Galvan Lack of antiparkinsonian effects of systemic injections of the specific T-type calcium channel blocker ML218 in MPTP-treated monkeys. ACS Chem.Neurosci 2016 PMID: 27596273
Chakraborty ML218 HCl is more efficient than capsaicin in inhibiting bacterial antigen-induced Cal 27 oral cancer cell proliferation. Int.J.Mol.Sci. 2021 PMID: 34830441
Xiang The discovery and characterization of ML218: A novel, centrally active T-type calcium channel inhibitor with robust effects in STN neurons and in a rodent model of Parkinson's disease. ACS Chem.Neurosci. 2011 PMID: 22368764