ML 190

Tocris Bioscience, part of Bio-Techne | Catalog # 4866

COA / SDS

Selective κ opioid receptor antagonist

Key Product Details

Description:	Selective κ opioid receptor antagonist
Chemical Name:	N-[3-[4-(4-Methoxyphenyl)-1-piperazinyl]propyl]-1-methyl-6-oxopyrido[2,3-e]pyrrolo[1,2-a]pyrazine-5(6H)-acetamide
Purity:	≥98% (HPLC)
Molecular Weight:	488.58

View Full Technical Details for ML 190

Technical Data
Citations

Biological Activity for ML 190

ML 190 is a selective κ opioid receptor (KOP) antagonist (IC₅₀ = 120 nM in a β-arrestin assay); displays >267-fold selectivity over μ and δ opioid receptors.

Technical Data for ML 190

M. Wt	488.58
Formula	C₂₇H₃₂N₆O₃
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	1355244-02-8
PubChem ID	44665680
InChi Key	PMTIWRPLQBVEMR-UHFFFAOYSA-N
Smiles	O=C(CN4C(C3=CC=CN3C5=C4N=CC=C5C)=O)NCCCN(CC2)CCN2C1=CC=C(OC)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 190

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	9.77	20

Preparing Stock Solutions for ML 190

The following data is based on the product molecular weight 488.58.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	10.23 mL	51.17 mL	102.34 mL
1 mM	2.05 mL	10.23 mL	20.47 mL
2 mM	1.02 mL	5.12 mL	10.23 mL
10 mM	0.20 mL	1.02 mL	2.05 mL

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Reconstitution Calculator

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References for ML 190

References are publications that support the biological activity of the product.

Hedrick Antagonist for the kappa opioid receptor. Probe Reports from the NIH Molecular Libraries Pro 2011 PMID: 22091479
Frankowski Discovery of small molecule kappa opioid receptor agonist and antagonist chemotypes through a HTS and hit refinement strategy. ACS Chem.Neurosci. 2012 PMID: 22737280