ML 190
Tocris Bioscience, part of Bio-Techne | Catalog # 4866
Selective κ opioid receptor antagonist
Key Product Details
Description
Selective κ opioid receptor antagonist
Product Description
ML 190 is a selective κ opioid receptor (KOP) antagonist (IC50 = 120 nM in a β-arrestin assay); displays >267-fold selectivity over μ and δ opioid receptors.Product Specifications
Molecular Weight
488.58
Formula
C27H32N6O3
Storage
Store at +4°C
Purity
≥98% (HPLC)
Chemical Name
N-[3-[4-(4-Methoxyphenyl)-1-piperazinyl]propyl]-1-methyl-6-oxopyrido[2,3-e]pyrrolo[1,2-a]pyrazine-5(6H)-acetamide
CAS Number
1355244-02-8
PubChem ID
44665680
InChI Key
PMTIWRPLQBVEMR-UHFFFAOYSA-N
SMILES
O=C(CN4C(C3=CC=CN3C5=C4N=CC=C5C)=O)NCCCN(CC2)CCN2C1=CC=C(OC)C=C1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.77 | 20 |
Preparing Stock Solutions
for ML 190
The following data is based on the product molecular weight 488.58
Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 10.23 mL | 51.17 mL | 102.34 mL |
| 1 mM | 2.05 mL | 10.23 mL | 20.47 mL |
| 2 mM | 1.02 mL | 5.12 mL | 10.23 mL |
| 10 mM | 0.20 mL | 1.02 mL | 2.05 mL |
Calculators
Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Background References
References are publications that support the biological activity of the product.
- Hedrick Antagonist for the kappa opioid receptor. Probe Reports from the NIH Molecular Libraries Pro 2011 PMID: 22091479
- Frankowski Discovery of small molecule kappa opioid receptor agonist and antagonist chemotypes through a HTS and hit refinement strategy. ACS Chem.Neurosci. 2012 PMID: 22737280
Product Specific Notices for ML 190
For research use only
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