ML 179

Name: ML 179
Brand: Tocris Bioscience
SKU: 4957
Rating: 4 (1 reviews)

Tocris Bioscience a Bio-Techne Brand

Catalog # 4957

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Key Product Details

Description:	Selective liver receptor homolog 1 (LRH1) inverse agonist
Chemical Name:	3-Cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1H-pyrimidine-2,4-dione
Purity:	≥99% (HPLC)
Molecular Weight:	422.44

View Full Technical Details for ML 179

Biological Activity for ML 179

ML 179 is a selective liver receptor homolog 1 (LRH1, NR5A2) inverse agonist (IC₅₀ = 320 nM and maximum efficacy of 64% repression). Exhibits >31-fold selectivity over SF1.

Technical Data for ML 179

M. Wt	422.44
Formula	C₂₁H₂₅F₃N₄O₂
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	1883548-87-5
PubChem ID	45100448
InChi Key	MFABFKUNLDYKGH-UHFFFAOYSA-N
Smiles	O=C(C=C(N3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3)NC2=O)N2C1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ML 179

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	21.12	50

Preparing Stock Solutions for ML 179

The following data is based on the product molecular weight 422.44.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.73 mL	23.67 mL	47.34 mL
2.5 mM	0.95 mL	4.73 mL	9.47 mL
5 mM	0.47 mL	2.37 mL	4.73 mL
25 mM	0.09 mL	0.47 mL	0.95 mL

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References for ML 179

References are publications that support the biological activity of the product.

Busby Discovery of inverse agonists for the liver receptor homologue-1 (LRH1; NR5A2). Probe Reports from the NIH Molecular Libraries Program 2010 PMID: 23166964

Citations for ML 179

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Customer Reviews for ML 179 (1)

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Selective liver receptor homolog 1 (LRH1) inverse agonist

Name: Anonymous

Species: Human

Assay Type: In Vitro

Cell Line/Tissue: BT-474

breast cancer cells line

Dilution buffer 100% DMSO for a stock solution at 10mM, used in a cell line where it showed a potent activity (breast cancer cells; IC50 values of 370nM).

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Product Documents for ML 179

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.